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Lipsome Dermatics : Mit 119 Abbildungen und 48 Tabellen : Griesbach Konferenz / Griesbach Conference - Otto Braun-Falco

Lipsome Dermatics : Mit 119 Abbildungen und 48 Tabellen

Griesbach Konferenz / Griesbach Conference

By: Otto Braun-Falco (Editor), Hans C. Korting (Editor), Howard I. Maibach (Editor)

Paperback ISBN: 9783540556466
Number Of Pages: 364

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Using a multi-disciplinary approach, this study deals with liposome dermatics from the chemist's, pharmacist's, biologist's as well as clinician's point of view. It features material on the production of liposomes; appropriate raw materials; encapsulation of active ingredients and their possible incorporation into vehicles such as gels; assessment of stability; the fate of liposomes and active ingredients exposed to animal and human skin both in vitro and in vivo; and the activity of topical liposome preparations in normal and inflamed skin in animal and man as well as their efficacy in skin diseases in man.

Preface
Introduction
General Considerations
Percutaneous Absorption and Conventional Penetration Enhancersp. 3
Lipid Flow Phenomena Between Liposomes, Lipoproteins and Cell Membranes; Applications in Drug Deliveryp. 11
Basic Principles of Liposomes for Drug Usep. 20
Chemical Aspects
Phospholipids as Basic Ingredientsp. 29
Liposome Dermatics: Chemical Aspects of the Skin Lipid Approachp. 38
Ceramides for Liposomesp. 44
Liposome Phospholipids: Toxicological and Environmental Advantagesp. 57
Physico-chemical Aspects
Liposome Production: Historic Aspectsp. 69
Rationale for the Production and Dermal Application of Lipid Vesiclesp. 82
Liposome Production: The Ethanol Injection Technique and the Development of the First Approved Liposome Dermaticp. 91
Liposome Production: The Sizing-Up Technology Starting from Mixed Micelles and the Scaling-Up Procedure for the Topical Glucocorticoid Betamethasone Dipropionate and Betamethasonep. 101
Properties and Characterization of Pre-Liposome Systemsp. 110
Technological Aspects
Changes in the Structure of the Human Stratum Corneum Induced by Liposomesp. 121
Monitoring in vivo Skin Hydration by Liposomes Using Infrared Spectroscopy in Conjunction with Tape Strippingp. 137
Liposome Dermatics: Assessment of Long-Term Stabilityp. 150
Delivery of Liposome-Encapsulated Agents to Artificial Membranesp. 167
Topical Delivery of Liposomally Encapsulated Ingredients Evaluated by In Vitro Diffusion Studiesp. 172
Pre-Clinical Aspects: Kinetics and Toxicology
The Fate of Liposomes in Animal Skinp. 185
The Fate of Liposomes for Topical Use in Skin Tissue Culturep. 195
Liposomally Encapsulated Active Ingredients Penetrate Through the Folliclep. 200
Biodisposition of Liposome-Encapsulated Active Ingredients Applied on the Skinp. 206
Distribution of Liposome-Encapsulated Ingredients in Human Skin Ex Vivop. 215
Liposomes as Safe Carriers of Drugs and Vaccinesp. 226
Pre-Clinical Aspects: Dynamics
Comedolytic Activity of a Liposomal Antiacne Drug in an Experimental Modelp. 235
Topical Delivery of Liposomally Encapsulated Interferon Evaluated by in Vitro Diffusion Studies and in a Cutaneous Herpes Guinea Pig Modelp. 242
Comparative Activity of a Liposomal and a Conventional Econazole Preparation for Topical Use According to a Guinea Pig Tinea Modelp. 251
Liposome-Encapsulated Enzymes for DNA Repairp. 258
Patent and Regulatory Aspects
General Remarks on Patent Matterp. 273
Liposome Determatics to Come According to the Patent Literaturep. 281
Clinical Regulatory Aspects of Topical Liposomal Drugs with Special Consideration of Safety Aspectsp. 288
Clinical Aspects
Clinical Trial Protocols for Anti-Inflammatory and other Liposome Dermaticsp. 299
Chemical Composition of Liposomes and Its Influence on the Humidity of Normal Skinp. 308
Influence of Various Topical Liposome Preparations With and Without Active Ingredients on the Cutaneous Blood Flowp. 315
Increased Activity and Tolerability of a Conventional Glucocorticoid in a Liposomal Formp. 320
Influence of Liposomal Encapsulation on the Activity of a Herbal Non-Steroidal Anti-Inflammatory Drugp. 329
Future Prospects
Past, Present and Future of Liposome Cosmeticsp. 341
Liposomes in Drug Delivery: Present and Futurep. 346
Subject Indexp. 353
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540556466
ISBN-10: 354055646X
Series: Griesbach Konferenz / Griesbach Conference
Audience: General
Format: Paperback
Language: English
Number Of Pages: 364
Publisher: SPRINGER VERLAG GMBH
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6  x 2.01
Weight (kg): 0.54