


Hardcover
Published: 19th September 2005
ISBN: 9780120802616
Number Of Pages: 650
A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included.
* Two-color, user-friendly format, with copious illustrations and color plates
* Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques
"...provides research scientists in academia and industry with comprehensive, practical information on laboratory animals...a welcome and necessary addition to the series of handbooks...this book is recommended to all researchers and students in biological, pharmaceutical, veterinary and medical sciences." -M. Schmidt, in JZS
Preface | p. xiii |
Definition of the Primate Model | |
The Taxonomy of Primates in the Laboratory Context | p. 3 |
Taxonomy: Organizing nature | p. 3 |
What are species? The biological species concept | p. 3 |
What are species? The phylogenetic species concept | p. 5 |
What are subspecies? | p. 5 |
Nomenclature | p. 6 |
How to classify species | p. 6 |
References | p. 13 |
Appendix | p. 15 |
Similarities of Non-human Primates to Humans: Genetic Variations and Phenotypic Associations Common to Rhesus Monkeys and Humans | p. 17 |
Introduction | p. 17 |
Mu-opioid receptor | p. 19 |
Dopamine transporter | p. 21 |
Serotonin transporter | p. 25 |
Conclusion | p. 26 |
References | p. 26 |
General Anatomy | p. 29 |
Introduction: Primates as a clade | p. 29 |
The musculoskeletal system | p. 30 |
The dentition | p. 34 |
The digestive system | p. 36 |
The brain | p. 37 |
Reproduction and life history variation | p. 38 |
The senses | p. 42 |
References | p. 43 |
Pathology of Noninfectious Diseases of the Laboratory Primate | p. 47 |
Introduction | p. 47 |
Respiratory system | p. 47 |
Cardiovascular system | p. 48 |
Endocrine system | p. 49 |
Alimentary tract | p. 50 |
Urinary system | p. 55 |
Reproductive system | p. 55 |
Nervous system | p. 59 |
Integumentary system | p. 62 |
Musculoskeletal system | p. 64 |
Multisystemic diseases | p. 65 |
References | p. 68 |
Common Viral Infections of Laboratory Primates | p. 75 |
Introduction | p. 75 |
Retroviruses | p. 75 |
Herpesviruses | p. 80 |
Parvoviruses | p. 83 |
Polyomaviruses | p. 84 |
References | p. 85 |
Modeling Parasitic Diseases in Nonhuman Primates: malaria, Chagas' Disease, and Filariasis | p. 91 |
Introduction | p. 91 |
Nonhuman primate models of malaria | p. 91 |
Nonhuman primate models of Chagas' disease | p. 95 |
Nonhuman primate models of lymphatic filariasis | p. 97 |
Concluding remarks | p. 99 |
References | p. 99 |
Reproduction: Definition of a Primate Model of Female Fertility | p. 105 |
Introduction | p. 105 |
Fertility | p. 107 |
Behavioural signs of reproductive activity | p. 107 |
Endocrinology and reproduction | p. 109 |
External factors influencing reproduction | p. 110 |
Infertility | p. 111 |
Summary | p. 114 |
References | p. 115 |
Male Reproduction and Fertilization | p. 119 |
Introduction | p. 119 |
Control of male reproduction | p. 119 |
Factors affecting male reproduction | p. 122 |
Fertilization | p. 125 |
In vitro fertilization | p. 127 |
Senescence | p. 128 |
References | p. 128 |
Primate Natural History and Social Behavior: Implications for Laboratory Housing | p. 133 |
Introduction | p. 133 |
Rhesus macaque natural history | p. 134 |
Laboratory environment and abnormal behavior | p. 136 |
Conclusions | p. 140 |
References | p. 140 |
Primate Management | |
Husbandry and Management of New World Species: Marmosets and Tamarins | p. 145 |
Animals and natural habitat | p. 145 |
Husbandry and housing | p. 146 |
Feeding and nutrition | p. 147 |
Environmental enrichment | p. 151 |
Breeding | p. 152 |
Physiological data | p. 154 |
Veterinary care | p. 155 |
Diseases | p. 157 |
Abbreviations | p. 160 |
References | p. 160 |
Management of Old World Primates | p. 163 |
Introduction | p. 163 |
Housing | p. 163 |
The Tsukuba experience | p. 165 |
References | p. 173 |
Vervet Monkey Breeding | p. 175 |
Introduction: breeding biology | p. 175 |
Breeding and rearing systems in captivity | p. 175 |
The menstrual cycle | p. 176 |
Mating, conception, pregnancy and birth | p. 176 |
References | p. 179 |
Nutrition and Nutritional Diseases | p. 181 |
Introduction | p. 181 |
Nutrient requirements | p. 182 |
Nonhuman primate diet formulations | p. 201 |
Food contaminants | p. 202 |
References | p. 203 |
Environmental Enrichment and Refinement of Handling Procedures | p. 209 |
Introduction | p. 209 |
Environmental enrichment | p. 210 |
Training for cooperation during procedures | p. 219 |
Conclusion | p. 221 |
References | p. 222 |
Development of Specific Pathogen Free Nonhuman Primate Colonies | p. 229 |
Introduction | p. 229 |
Historical perspectives on specific pathogen free primate colonies | p. 229 |
Definition of specific pathogen free status | p. 230 |
SPF target viruses for macaque colonies | p. 230 |
SPF target agents in non-macaque primate colonies | p. 232 |
Viral testing | p. 232 |
Specific pathogen free animal derivation strategies | p. 234 |
Animal housing configurations | p. 235 |
Veterinary care program | p. 235 |
Expanded SPF programs | p. 236 |
Summary recommendations | p. 237 |
References | p. 238 |
Medical Care | p. 241 |
Animal health monitoring and surveillance | p. 241 |
Management of the stable colony | p. 242 |
Management of quarantine and isolation | p. 249 |
Personnel health monitoring and surveillance policies | p. 250 |
First aid and critical care | p. 251 |
Emergency animal care | p. 253 |
Concluding remarks | p. 256 |
References | p. 256 |
Factors Affecting the Choice of Species | p. 259 |
Introduction | p. 259 |
Factors affecting choice | p. 260 |
Inter and intraspecies variations in pharmaceutical use | p. 267 |
Conclusions | p. 269 |
References | p. 270 |
Research Techniques and Procedures | |
Anaesthesia | p. 275 |
Introduction | p. 275 |
Anaesthesia | p. 275 |
Drug administration and sample collection | p. 290 |
References | p. 291 |
Rigid Endoscopy | p. 293 |
Introduction | p. 293 |
Laparoscopy | p. 294 |
Laparoscopic procedures | p. 303 |
Thoracoscopy | p. 313 |
Thoracoscopic procedures | p. 315 |
Summary comments | p. 316 |
References | p. 316 |
Ultrasound Imaging in Rhesus (Macaca mulatta) and Long-tailed (Macaca fascicularis) Macaques: Reproductive and Research Applications | p. 317 |
Introduction | p. 317 |
Equipment and scanning techniques | p. 318 |
Nongravid animals | p. 319 |
Gravid animals | p. 323 |
Fetal development | p. 329 |
Ultrasound-guided procedures | p. 345 |
Other ultrasound imaging applications | p. 346 |
References | p. 349 |
Functional Magnetic Resonance Imaging in Conscious Marmoset Monkeys: Methods and Applications in Neuroscience Research | p. 353 |
Introduction | p. 353 |
What is fMRI and how does it work? | p. 355 |
Problems associated with fMRI in nonhuman animals | p. 359 |
Applications in neuroscience research | p. 366 |
References | p. 369 |
Radiographic Imaging of Nonhuman Primates | p. 371 |
Introduction | p. 371 |
Thoracic radiograph | p. 371 |
Abdominal radiograph | p. 374 |
Neurologic system | p. 382 |
Musculoskeletal | p. 383 |
Fluoroscopy | p. 385 |
Nuclear imaging | p. 385 |
References | p. 385 |
Imaging: Positron Emission Tomography (PET) | p. 387 |
Introduction | p. 387 |
Principles of emission computed tomography | p. 389 |
Non-human primate PET scanners | p. 394 |
Animal procedures for PET studies | p. 395 |
Anaesthesia and immobilization | p. 397 |
PET application in non-human primates | p. 398 |
Imaging non-human primates versus rodents | p. 399 |
References | p. 400 |
Current Uses in Biomedical Research | |
Use of the Primate Model in Research | p. 405 |
Introduction | p. 405 |
Primatology: An historical overview | p. 406 |
Anatomy/physiology | p. 407 |
Development of the primate model in research | p. 407 |
Research utilization and advances | p. 408 |
Welfare considerations | p. 411 |
References | p. 413 |
Chronic Diseases | p. 417 |
Summary | p. 417 |
Introduction | p. 417 |
The rhesus monkey model of collagen-induced arthritis (CIA) | p. 418 |
Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) | p. 422 |
Myasthenia gravis | p. 430 |
References | p. 433 |
Practical Approaches to Pharmacological Studies in Nonhuman Primates | p. 437 |
Introduction | p. 437 |
The nonhuman primate in pharmacological studies | p. 437 |
Drug and test compound delivery | p. 440 |
Behavior analysis as an aid in pharmacological research | p. 444 |
Current pharmacological research in the nonhuman primate model | p. 445 |
Conclusion | p. 446 |
References | p. 446 |
Nonhuman Primate Models of Human Aging | p. 449 |
Background | p. 449 |
Approach | p. 450 |
Measurement of cognitive status | p. 450 |
Diet and cardiovascular health | p. 451 |
Primate diversity | p. 451 |
Major topics of primate aging research | p. 451 |
References | p. 463 |
Primate Models of Neurological Disease | p. 467 |
Introduction | p. 467 |
Amnestic syndromes | p. 467 |
Parkinson's disease | p. 472 |
Alzheimer's disease and amyloid angiopathy | p. 477 |
Multiple sclerosis | p. 478 |
Epilepsy | p. 479 |
Summary | p. 482 |
References | p. 482 |
Genetics: A Survey of Nonhuman Primate Genetics, Genetic Management and Applications to Biomedical Research | p. 487 |
The analysis of primate genomes | p. 487 |
Genetic relationships among primates | p. 491 |
Genetic management of primates | p. 493 |
Current applications to biomedical research | p. 495 |
Future directions in primate genetics | p. 497 |
References | p. 498 |
The Respiratory System and its Use in Research | p. 503 |
Introduction | p. 503 |
Nasal cavity | p. 504 |
Pharynx | p. 511 |
Larynx | p. 512 |
Lung organization | p. 512 |
Tracheobronchial airways | p. 512 |
Gas exchange area | p. 516 |
Overview of research uses | p. 518 |
References | p. 522 |
Reproduction: Male | p. 527 |
Introduction | p. 527 |
Which non-human primate models are used/or should be used? | p. 527 |
Main applications in male reproduction: models for biomedical research | p. 529 |
References | p. 535 |
Reproduction: Female | p. 537 |
Historical perspective | p. 537 |
Follicular growth and ovulation | p. 538 |
Induced ovulation | p. 539 |
Ovum and embryo recovery techniques | p. 541 |
Production of precisely aged embryos | p. 541 |
Contraceptive effects | p. 543 |
Embryo transfer | p. 543 |
In vitro fertilization | p. 544 |
Other manipulative techniques and future clinical application | p. 545 |
Conclusion | p. 546 |
References | p. 546 |
The Baboon as an Appropriate Model for the Study of Multifactoral Aspects of Human Endometriosis | p. 549 |
Introduction | p. 549 |
Animal models for endometriosis research | p. 550 |
The role of the baboon model for study of human endometriosis | p. 552 |
Conclusion | p. 557 |
References | p. 557 |
Virology Research | p. 561 |
Introduction and scope | p. 561 |
Acute viral diseases | p. 562 |
Chronic viral diseases | p. 564 |
Conclusion | p. 573 |
References | p. 574 |
Parasitic Diseases of Nonhuman Primates | p. 579 |
Introduction | p. 579 |
Parasitic diseases of immune-competent nonhuman primates | p. 579 |
Parasitic diseases of immune-compromised nonhuman primates | p. 584 |
Commonly occurring benign parasitic infections of nonhuman primates | p. 587 |
Concluding remarks | p. 589 |
References | p. 590 |
Glossary | p. 595 |
Index | p. 607 |
Table of Contents provided by Ingram. All Rights Reserved. |
ISBN: 9780120802616
ISBN-10: 0120802619
Series: Handbook of Experimental Animals
Audience:
Professional
Format:
Hardcover
Language:
English
Number Of Pages: 650
Published: 19th September 2005
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 27.9 x 20.3
x 3.18
Weight (kg): 1.93