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Laboratory Primate : Handbook of Experimental Animals - Sonia Wolfe-Coote

Laboratory Primate

Handbook of Experimental Animals

Hardcover Published: 19th September 2005
ISBN: 9780120802616
Number Of Pages: 650

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A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included.
* Two-color, user-friendly format, with copious illustrations and color plates
* Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

"...provides research scientists in academia and industry with comprehensive, practical information on laboratory animals...a welcome and necessary addition to the series of handbooks...this book is recommended to all researchers and students in biological, pharmaceutical, veterinary and medical sciences." -M. Schmidt, in JZS

Prefacep. xiii
Definition of the Primate Model
The Taxonomy of Primates in the Laboratory Contextp. 3
Taxonomy: Organizing naturep. 3
What are species? The biological species conceptp. 3
What are species? The phylogenetic species conceptp. 5
What are subspecies?p. 5
Nomenclaturep. 6
How to classify speciesp. 6
Referencesp. 13
Appendixp. 15
Similarities of Non-human Primates to Humans: Genetic Variations and Phenotypic Associations Common to Rhesus Monkeys and Humansp. 17
Introductionp. 17
Mu-opioid receptorp. 19
Dopamine transporterp. 21
Serotonin transporterp. 25
Conclusionp. 26
Referencesp. 26
General Anatomyp. 29
Introduction: Primates as a cladep. 29
The musculoskeletal systemp. 30
The dentitionp. 34
The digestive systemp. 36
The brainp. 37
Reproduction and life history variationp. 38
The sensesp. 42
Referencesp. 43
Pathology of Noninfectious Diseases of the Laboratory Primatep. 47
Introductionp. 47
Respiratory systemp. 47
Cardiovascular systemp. 48
Endocrine systemp. 49
Alimentary tractp. 50
Urinary systemp. 55
Reproductive systemp. 55
Nervous systemp. 59
Integumentary systemp. 62
Musculoskeletal systemp. 64
Multisystemic diseasesp. 65
Referencesp. 68
Common Viral Infections of Laboratory Primatesp. 75
Introductionp. 75
Retrovirusesp. 75
Herpesvirusesp. 80
Parvovirusesp. 83
Polyomavirusesp. 84
Referencesp. 85
Modeling Parasitic Diseases in Nonhuman Primates: malaria, Chagas' Disease, and Filariasisp. 91
Introductionp. 91
Nonhuman primate models of malariap. 91
Nonhuman primate models of Chagas' diseasep. 95
Nonhuman primate models of lymphatic filariasisp. 97
Concluding remarksp. 99
Referencesp. 99
Reproduction: Definition of a Primate Model of Female Fertilityp. 105
Introductionp. 105
Fertilityp. 107
Behavioural signs of reproductive activityp. 107
Endocrinology and reproductionp. 109
External factors influencing reproductionp. 110
Infertilityp. 111
Summaryp. 114
Referencesp. 115
Male Reproduction and Fertilizationp. 119
Introductionp. 119
Control of male reproductionp. 119
Factors affecting male reproductionp. 122
Fertilizationp. 125
In vitro fertilizationp. 127
Senescencep. 128
Referencesp. 128
Primate Natural History and Social Behavior: Implications for Laboratory Housingp. 133
Introductionp. 133
Rhesus macaque natural historyp. 134
Laboratory environment and abnormal behaviorp. 136
Conclusionsp. 140
Referencesp. 140
Primate Management
Husbandry and Management of New World Species: Marmosets and Tamarinsp. 145
Animals and natural habitatp. 145
Husbandry and housingp. 146
Feeding and nutritionp. 147
Environmental enrichmentp. 151
Breedingp. 152
Physiological datap. 154
Veterinary carep. 155
Diseasesp. 157
Abbreviationsp. 160
Referencesp. 160
Management of Old World Primatesp. 163
Introductionp. 163
Housingp. 163
The Tsukuba experiencep. 165
Referencesp. 173
Vervet Monkey Breedingp. 175
Introduction: breeding biologyp. 175
Breeding and rearing systems in captivityp. 175
The menstrual cyclep. 176
Mating, conception, pregnancy and birthp. 176
Referencesp. 179
Nutrition and Nutritional Diseasesp. 181
Introductionp. 181
Nutrient requirementsp. 182
Nonhuman primate diet formulationsp. 201
Food contaminantsp. 202
Referencesp. 203
Environmental Enrichment and Refinement of Handling Proceduresp. 209
Introductionp. 209
Environmental enrichmentp. 210
Training for cooperation during proceduresp. 219
Conclusionp. 221
Referencesp. 222
Development of Specific Pathogen Free Nonhuman Primate Coloniesp. 229
Introductionp. 229
Historical perspectives on specific pathogen free primate coloniesp. 229
Definition of specific pathogen free statusp. 230
SPF target viruses for macaque coloniesp. 230
SPF target agents in non-macaque primate coloniesp. 232
Viral testingp. 232
Specific pathogen free animal derivation strategiesp. 234
Animal housing configurationsp. 235
Veterinary care programp. 235
Expanded SPF programsp. 236
Summary recommendationsp. 237
Referencesp. 238
Medical Carep. 241
Animal health monitoring and surveillancep. 241
Management of the stable colonyp. 242
Management of quarantine and isolationp. 249
Personnel health monitoring and surveillance policiesp. 250
First aid and critical carep. 251
Emergency animal carep. 253
Concluding remarksp. 256
Referencesp. 256
Factors Affecting the Choice of Speciesp. 259
Introductionp. 259
Factors affecting choicep. 260
Inter and intraspecies variations in pharmaceutical usep. 267
Conclusionsp. 269
Referencesp. 270
Research Techniques and Procedures
Anaesthesiap. 275
Introductionp. 275
Anaesthesiap. 275
Drug administration and sample collectionp. 290
Referencesp. 291
Rigid Endoscopyp. 293
Introductionp. 293
Laparoscopyp. 294
Laparoscopic proceduresp. 303
Thoracoscopyp. 313
Thoracoscopic proceduresp. 315
Summary commentsp. 316
Referencesp. 316
Ultrasound Imaging in Rhesus (Macaca mulatta) and Long-tailed (Macaca fascicularis) Macaques: Reproductive and Research Applicationsp. 317
Introductionp. 317
Equipment and scanning techniquesp. 318
Nongravid animalsp. 319
Gravid animalsp. 323
Fetal developmentp. 329
Ultrasound-guided proceduresp. 345
Other ultrasound imaging applicationsp. 346
Referencesp. 349
Functional Magnetic Resonance Imaging in Conscious Marmoset Monkeys: Methods and Applications in Neuroscience Researchp. 353
Introductionp. 353
What is fMRI and how does it work?p. 355
Problems associated with fMRI in nonhuman animalsp. 359
Applications in neuroscience researchp. 366
Referencesp. 369
Radiographic Imaging of Nonhuman Primatesp. 371
Introductionp. 371
Thoracic radiographp. 371
Abdominal radiographp. 374
Neurologic systemp. 382
Musculoskeletalp. 383
Fluoroscopyp. 385
Nuclear imagingp. 385
Referencesp. 385
Imaging: Positron Emission Tomography (PET)p. 387
Introductionp. 387
Principles of emission computed tomographyp. 389
Non-human primate PET scannersp. 394
Animal procedures for PET studiesp. 395
Anaesthesia and immobilizationp. 397
PET application in non-human primatesp. 398
Imaging non-human primates versus rodentsp. 399
Referencesp. 400
Current Uses in Biomedical Research
Use of the Primate Model in Researchp. 405
Introductionp. 405
Primatology: An historical overviewp. 406
Anatomy/physiologyp. 407
Development of the primate model in researchp. 407
Research utilization and advancesp. 408
Welfare considerationsp. 411
Referencesp. 413
Chronic Diseasesp. 417
Summaryp. 417
Introductionp. 417
The rhesus monkey model of collagen-induced arthritis (CIA)p. 418
Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE)p. 422
Myasthenia gravisp. 430
Referencesp. 433
Practical Approaches to Pharmacological Studies in Nonhuman Primatesp. 437
Introductionp. 437
The nonhuman primate in pharmacological studiesp. 437
Drug and test compound deliveryp. 440
Behavior analysis as an aid in pharmacological researchp. 444
Current pharmacological research in the nonhuman primate modelp. 445
Conclusionp. 446
Referencesp. 446
Nonhuman Primate Models of Human Agingp. 449
Backgroundp. 449
Approachp. 450
Measurement of cognitive statusp. 450
Diet and cardiovascular healthp. 451
Primate diversityp. 451
Major topics of primate aging researchp. 451
Referencesp. 463
Primate Models of Neurological Diseasep. 467
Introductionp. 467
Amnestic syndromesp. 467
Parkinson's diseasep. 472
Alzheimer's disease and amyloid angiopathyp. 477
Multiple sclerosisp. 478
Epilepsyp. 479
Summaryp. 482
Referencesp. 482
Genetics: A Survey of Nonhuman Primate Genetics, Genetic Management and Applications to Biomedical Researchp. 487
The analysis of primate genomesp. 487
Genetic relationships among primatesp. 491
Genetic management of primatesp. 493
Current applications to biomedical researchp. 495
Future directions in primate geneticsp. 497
Referencesp. 498
The Respiratory System and its Use in Researchp. 503
Introductionp. 503
Nasal cavityp. 504
Pharynxp. 511
Larynxp. 512
Lung organizationp. 512
Tracheobronchial airwaysp. 512
Gas exchange areap. 516
Overview of research usesp. 518
Referencesp. 522
Reproduction: Malep. 527
Introductionp. 527
Which non-human primate models are used/or should be used?p. 527
Main applications in male reproduction: models for biomedical researchp. 529
Referencesp. 535
Reproduction: Femalep. 537
Historical perspectivep. 537
Follicular growth and ovulationp. 538
Induced ovulationp. 539
Ovum and embryo recovery techniquesp. 541
Production of precisely aged embryosp. 541
Contraceptive effectsp. 543
Embryo transferp. 543
In vitro fertilizationp. 544
Other manipulative techniques and future clinical applicationp. 545
Conclusionp. 546
Referencesp. 546
The Baboon as an Appropriate Model for the Study of Multifactoral Aspects of Human Endometriosisp. 549
Introductionp. 549
Animal models for endometriosis researchp. 550
The role of the baboon model for study of human endometriosisp. 552
Conclusionp. 557
Referencesp. 557
Virology Researchp. 561
Introduction and scopep. 561
Acute viral diseasesp. 562
Chronic viral diseasesp. 564
Conclusionp. 573
Referencesp. 574
Parasitic Diseases of Nonhuman Primatesp. 579
Introductionp. 579
Parasitic diseases of immune-competent nonhuman primatesp. 579
Parasitic diseases of immune-compromised nonhuman primatesp. 584
Commonly occurring benign parasitic infections of nonhuman primatesp. 587
Concluding remarksp. 589
Referencesp. 590
Glossaryp. 595
Indexp. 607
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780120802616
ISBN-10: 0120802619
Series: Handbook of Experimental Animals
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 650
Published: 19th September 2005
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 27.9 x 20.3  x 3.18
Weight (kg): 1.93