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Kinetics for the Life Sciences : Receptors, Transmitters and Catalysts - H. Gutfreund

Kinetics for the Life Sciences

Receptors, Transmitters and Catalysts

Paperback

Published: 13th November 1995
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This book introduces the reader to the kinetic analysis of a wide range of biological processes at the molecular level. It shows that the same approach can be used to resolve the number of steps for a wide range of systems including enzyme reactions, muscle contraction, visual perception, and ligand binding. The author discusses the methods for characterizing these steps in chemical terms. Firmly rooted in theory, a wide range of examples and experimental techniques are introduced as well. A historical approach is used to demonstrate the development of the theory and experimental techniques of kinetic analysis in biology.

'... this well-written text will appeal to the advanced biochemistry student and beyond'. New Scientist '... a thought-provoking treatise on the ways to apply kinetics in different biological systems, certainly worth a look at by current researchers in this field'. Chris Cooper, Chemistry in Britain

The Time Scales of Nature: a Historical Survey
The history of the application of physical principles
Kinetics and biological problems
Time scales of nature and of measurement
Some Mathematical Introductions
The origins of exponential behaviour
Modelling of kinetic systems
Data collection, reduction and analysis
Guidelines for the derivation of equations used in the text
Elementary Kinetic Equations: Ground Rules
The law of mass action, rates and equilibria
The evaluation of first and second order rate constants
An introduction to practical steady state kinetics
Steady state kinetics of reversible effectors and ionic equilibria
Kinetic Analysis of Complex Reactions
Introduction to the study of transients and reaction sequences
Consecutive reactions and physiological responses
Kinetic Mechanisms of Enzyme Reactions
Transient kinetics and enzyme reactions
Sequential enzyme reactions in metabolism and control
Kinetics of ligand dissociation and exchange between binding sites
Chemical Relaxation Phenomena
Applications of relaxation kinetics
Basic equations for the analysis of chemical relaxations
Chemical relaxation of ligand binding and recognition
Relaxations of proton equilibria
Factors Affecting the Rates of Chemical Reactions
Introduction to the history and concepts of chemical dynamics
Temperature dependence of reactions and the activation parameters
Viscosity and molecular dynamics
Diffusion control of reactions
Some comments on the use of isotopes in kinetic investigations
The Role of Light in Kinetic Investigations
Applications of photochemistry
Luminescence and other excited states
The scope of fluorescence life time studies
Photolabile (caged) compounds for the initiation of reactions
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521485869
ISBN-10: 052148586X
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 360
Published: 13th November 1995
Publisher: Cambridge University Press
Country of Publication: GB
Dimensions (cm): 22.8 x 15.2  x 2.0
Weight (kg): 0.58