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Itch : Basic Mechanisms and Therapy - Gil Yosipovitch


Basic Mechanisms and Therapy

By: Gil Yosipovitch (Editor), Malcolm W. Greaves (Editor), Alan B. Fleischer, Jr. (Editor), Francis McGlone (Editor)

Hardcover Published: 6th January 2004
ISBN: 9780824747473
Number Of Pages: 342

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Offering details on the pharmacology of itch, techniques of itch evaluation, and neurogenic itch, this reference presents new concepts in the neurophysiology and central mechanisms of itch, animal models of itch, and processing of histamine itch in the human cerebral cortex. The text clarifies itch in systemic and skin disease, exploring renal itch, uremic pruritus, lichen amyloidosis and more.

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"useful not only for dermatologists and non dermatologists who treat itching, but also for neurophysiologists, pharmacologists, and all the medical and chemical community interested in Cosmetic Dermatology." -Journal of Applied Cosmetology

Forewordp. vii
Prefacep. ix
Contributorsp. xv
Clinical Classification of Itch
Definitions of Itchp. 1
Basic Mechanisms of Itch
Neurophysiologic Basis of Itchp. 5
Pain and Itchp. 13
Central Neural Mechanisms of Itchp. 21
Animal Models of Itch: Scratching Away at the Problemp. 35
Histamine-Induced Discriminative and Affective Responses Revealed by Functional MRIp. 51
Central Nervous System Imaging of Itch with PETp. 63
Skin Nerve Anatomy: Neuropeptide Distribution and Its Relationship to Itchp. 71
Substance P and Itchp. 87
Peripheral Opiate Receptor System in Human Epidermis and Itchp. 97
Antipruritic Activity of a Novel [kappa]-Opioid Receptor Agonist, TRK-820p. 107
Putative Role of Cannabinoids in Experimentally Induced Itch and Inflammation in Human Skinp. 115
Itch Models in Animals, with Special Emphasis on the Serotonin Model in Ratsp. 131
Human Itch Models, with Special Emphasis on Itch in SLS-Inflamed and Normal Skinp. 139
Evaluation of Patients with Itch
Microdialysis in Itch Researchp. 147
Measuring Nocturnal Scratching in Atopic Dermatititsp. 161
Itch Questionnaires as Tools for Itch Evaluationp. 169
Epidemiology and Characteristics of Itch
Epidemiology of Itching in Skin and Systemic Diseasesp. 183
Uremic Pruritus: New Perspectives and Insights from Recent Trialsp. 193
Pruritus Complicating Liver Diseasep. 205
Itch in HIV-Infected Patientsp. 219
Neuropathic Pruritusp. 231
Clinical Features of Itch in Atopic Eczemap. 241
Postburn Itchp. 247
Pruritus in Lichen Simplex Chronicus and Lichen Amyloidosisp. 255
Treatment of Itch
Treatment of Pruritus in Internal and Dermatological Diseases with Opioid Receptor Antagonistsp. 259
Prospects for a Novel [kappa]-Opioid Receptor Agonist, TRK-820, in Uremic Pruritusp. 279
Treatment of Pruritic Skin Diseases with Topical Capsaicinp. 287
Mechanistic and Clinical Assessment of Zangrado, an Extract of the Amazonian Ethnomedicine Sangre de Grado, for the Treatment of Itchp. 305
Reduction in Itch Severity with Topical Immunomodulators: A New Approach for Patients with Inflammatory Diseasep. 315
5-HT[subscript 3] Receptor Antagonists as Antipruriticsp. 325
Cutaneous Nerve Stimulation in Treatment of Localized Itchp. 335
Social and Psychological Aspects
Psychosomatic Aspects of Pruritusp. 343
On Psychological Factors Affecting Reports of Itch Perceptionp. 351
Itching as a Focus of Mental Disturbancep. 369
Indexp. 377
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780824747473
ISBN-10: 082474747X
Series: Basic and Clinical Dermatology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 342
Published: 6th January 2004
Publisher: CRC PR INC
Country of Publication: US
Dimensions (cm): 23.5 x 15.24  x 2.54
Weight (kg): 0.67
Edition Number: 1

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