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Ischemic "Preconditioning" : The Concept of Endogenous Cardioprotection

The Concept of Endogenous Cardioprotection

By: Karin Przyklenk (Editor), Robert A. Kloner (Editor), Derek M. Yellon (Editor)

Hardcover Published: December 2009
ISBN: 9780792324102
Number Of Pages: 196

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Ischemic Preconditioning: The Concept of Endogenous Cardioprotection consolidates, in one volume, both current knowledge and the most recent advances in ischemic preconditioning. The editors have invited investigators at the forefront of ongoing research to provide their scholarly and candid comments concerning each of these issues. This volume includes a comprehensive review of infarct size reduction with ischemic preconditioning, and the most recent data on the effects of preconditioning on ischemia and reperfusion-induced arrhythmias, myocardial metabolism, contractile function, and the coronary vasculature. The role of altered energy metabolism, stress-induced proteins, ATP-sensitive potassium channels, and adenosine -- the major hypotheses that have been proposed to explain the cardioprotective effects of ischemic preconditioning -- are critically reviewed by investigators who have been instrumental in developing these concepts. In addition, the editors raise the intriguing possibility that ischemic preconditioning may be more than simply a laboratory curiosity. Using a multidisciplinary approach, this volume challenges the readers to contribute their own expertise to address the unanswered questions concerning this endogenous, cardioprotective phenomenon.

List of contributors
Ischemic Preconditioning: Benefits and Limitations in Experimental Models of Ischemia/Reperfusion
What is ischemic preconditioning?p. 3
Preconditioning and ischemia- and reperfusion-induced arrhythmiasp. 19
Preconditioning and myocardial contractile functionp. 41
Preconditioning and the coronary vasculaturep. 61
Mechanisms of Cardioprotection by Preconditioning: Theories and Controversies
Role of altered energy metabolism in ischemic preconditioningp. 75
Stress proteins, heat stress, and myocardial protectionp. 105
Role of ATP-sensitive potassium channels in ischemic preconditioningp. 125
Adenosine and the antiinfarct effects of preconditioningp. 137
Synopsis of ischemic preconditioning: What have we learned since 1986?p. 153
Ischemic Preconditioning: Laboratory Curiosity Or Clinical Promise?
Is preconditioning relevant to clinical medicine?p. 173
Indexp. 189
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792324102
ISBN-10: 0792324102
Series: Monographiae Biologicae
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 196
Published: December 2009
Publisher: Springer
Country of Publication: US
Dimensions (cm): 23.39 x 15.6  x 1.42
Weight (kg): 0.48

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