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Ionic Channels and Effect of Taurine on the Heart : DEVELOPMENTS IN CARDIOVASCULAR MEDICINE - Denis Noble

Ionic Channels and Effect of Taurine on the Heart


By: Denis Noble (Editor), Yung E. Earm (Editor)

Hardcover Published: 31st March 1993
ISBN: 9780792321996
Number Of Pages: 171

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This book is based on papers presented at a Symposium held in Seoul, Korea in 1992. The idea for the symposium developed naturally from work in which Professor Yung E Earm, at Seoul National University, had been involved both in my laboratory in Oxford and in his own laboratory in Seoul concerning the possible role of certain amino acids, like taurine that are strongly concentrated by the cells of the heart, and the relationship between such acids and membrane ionic currents. The first obvious question was whether it is possible to identify the transport mechanisms involved for taurine and whether they are electrogenic. The second question is what function could be served by such processes: does taurine play an essential role in cardiac tissue and is this important in protecting the heart from disease? With his colleagues in the Korean Physiological Society, Professor Earm set about the task of fmancing and organizing a meeting at which some of the world's leading cardiac electrophysiologists and taurine specialists could discuss these questions. The fmance was generously provided by the Dong-A Pharmaceutical Company, one of the leading scientific companies in Korea.

Introduction to the Study and Role of Background Current Mechanisms in the Heartp. 1
Catecholamine-Induced Chloride Current in Cardiac Myocytesp. 19
Modulation of the Atrial Muscarinic-Gated K Current by Phosphorylationp. 57
Intracellular Taurine, Intracellular Sodium and Defense Against Cellular Damagep. 73
Taurine Effects on Ion Channels of Cardiac Musclep. 93
Effect of Taurine on the Activation of Background Current in Cardiac Myocytes of the Rabbitp. 119
Protective Effect of Taurine on the Failing Heart and Its Clinical Applicationp. 139
Concluding Remarksp. 163
Indexp. 169
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792321996
ISBN-10: 0792321995
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 171
Published: 31st March 1993
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 1.2
Weight (kg): 0.98