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Ion Channel Regulation : Volume 33 - Paul Greengard

Ion Channel Regulation

Volume 33

By: Paul Greengard (Editor), Angus C. Nairn (Editor), Shirish Shenolikar (Editor), David L. Armstrong (Editor), Sandra Rossie (Editor)

Hardcover Published: 1st April 1999
ISBN: 9780120361335
Number Of Pages: 318

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Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases.
How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity.
Key Features
* Reviews brain functioning at the fundamental, molecular level
* Describes key systems that control signaling between and within cells
* Explains how channels are used to stimulate growth and changes to activity of the nucleus and genome

Overview: I.B. Levitan Modulation of Ion Channels by Protein Phosphorylation
Protein Phosphorylation
Regulation of Voltage-Sensitive Sodium and Calcium Channels by Phosphorylation
Regulation of Ligand Gated Ion Channels by Protein Phosphorylation
Regulations of CFTR Cl - Ion Channels by Phosphorylation and Dephosphorylation
Second Messengers: M. Biel
Cyclic GMP and Ion Channel Regulation
Closely Associated Proteins
Voltage-Dependent Modulation of N-Type Calcium Channels: Role of G Proteins Subunits
Novel Pathways
G Protein-Gated Potassium Channels
L Type Calcium Channel Modulation by G Proteins
Novel Pathways: S.G. Rane Ion Channels as Physiological Effectors for Growth Factor Receptor and Ras/ERK Signaling Pathways
Store-Operated Calcium Channels
Subject Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780120361335
ISBN-10: 0120361337
Series: Advances in Second Messenger & Phosphoprotein Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 318
Published: 1st April 1999
Country of Publication: US
Dimensions (cm): 23.67 x 15.85  x 1.88
Weight (kg): 0.59