| Contributors | p. ix |
| Cellular Mechanism for Targeting Heterochromatin Formation in Drosophila | p. 1 |
| Introduction | p. 2 |
| Heterochromatin Domains in the Drosophila Genome | p. 3 |
| DNA Sequences that Target Heterochromatin | p. 16 |
| Histone Modifications and Heterochromatin Targeting | p. 21 |
| Nonhistone Proteins and Heterochromatin Targeting | p. 23 |
| Nuclear Associations and Heterochromatin in Drosophila | p. 31 |
| Summary and Perspectives | p. 33 |
| References | p. 34 |
| Import of Nuclear-Encoded Mitochondrial Proteins: A Cotranslational Perspective | p. 49 |
| Introduction | p. 50 |
| Mitochondrial Assembly and Protein Import | p. 50 |
| Mitochondrial Protein Import: Posttranslational or Cotranslational? | p. 51 |
| Conclusions and Perspectives | p. 63 |
| References | p. 65 |
| Giant Siliceous Spicules From the Deep-Sea Glass Sponge Monorhaphis chuni | p. 69 |
| Introduction | p. 70 |
| Monorhaphis | p. 73 |
| Giant Basal Spicules: Morphology-Chemistry-Mechanics | p. 76 |
| Synthesis of Spicules in Demospongiae | p. 97 |
| Spicule Network in Sponges: A Unique Skeleton | p. 102 |
| Importance of the Findings for Nanobiotechnological Applications | p. 108 |
| Concluding Remarks | p. 109 |
| References | p. 110 |
| The Biology of Caveolae: Achievements and Perspectives | p. 117 |
| Introduction | p. 118 |
| Structure of Caveolae | p. 118 |
| Functions of Caveolae | p. 128 |
| Caveolin-1 and Caveolae as Therapeutic Targets | p. 141 |
| Concluding Remarks | p. 144 |
| References | p. 145 |
| Pharmacology of Ciliated Protozoa-Drug (In)Sensitivity and Experimental Drug (Ab)Use | p. 163 |
| Introduction | p. 164 |
| Early Success Story-Calmodulin and Its Effect on Ion Transport | p. 166 |
| Cation Channels, Pumps, and Exchangers | p. 168 |
| Functions of Specific Components | p. 179 |
| Cytoskeleton | p. 181 |
| Signaling, Intracellular Trafficking, and Signal Transduction | p. 188 |
| Other Factors and Tools | p. 195 |
| Concluding Remarks | p. 199 |
| References | p. 203 |
| Cell and Molecular Biology of Nuclear Actin | p. 219 |
| Introduction | p. 220 |
| Biological Functions of Nuclear Actin | p. 223 |
| Mechanisms of Actin Function in the Nucleus | p. 235 |
| Concluding Remarks | p. 249 |
| References | p. 250 |
| Small Ubiquitin-Like Modifiers in Cellular Malignancy and Metastasis | p. 265 |
| Introduction | p. 266 |
| SUMOs and SUMO-Modifying Enzymes | p. 267 |
| Roles of SUMOs in Cancer Development, Progression, and Metastasis | p. 286 |
| Concluding Remarks | p. 297 |
| References | p. 298 |
| Phosphoinositide Signaling Pathways: Promising Role as Builders of Epithelial Cell Polarity | p. 313 |
| Introduction | p. 314 |
| Phosphoinositides: Structure, Metabolism, and Functions | p. 315 |
| Phosphoinositides as Key Determinants in Building Polarity | p. 323 |
| Concluding Remarks | p. 334 |
| References | p. 335 |
| Index | p. 345 |
| Table of Contents provided by Ingram. All Rights Reserved. |