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International Review Neurobiology Vol 55 : Volume 55 - David S Latchman

International Review Neurobiology Vol 55

Volume 55

Hardcover Published: 22nd August 2003
ISBN: 9780123668561
Number Of Pages: 329

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Gene therapy offers considerable potential for the treatment of various incurable diseases of the nervous system. Viral Vectors for Treating Disease of the Nervous System describes a number of different viral vectors developed for achieving high efficiency gene delivery to the brain. Vectors described include those based on adenovirus, adeno-associated virus, Herpes Simplex Virus, lentivirus, and other retroviruses. It also discusses the potential application of such viruses in treating brain tumors, Parkinson's disease, and other diseases of the nervous system.

  • Provides up-to-date account of gene therapy approaches for incurable neurological disorders
  • Describes a range of gene delivery methods based on different viruses

Contributorsp. ix
Virus Vectors for Use in the Central Nervous System
Nonneurotropic Adenovirus: A Vector for Gene Transfer to the Brain and Gene Therapy of Neurological Disorders
Introduction: Some History and Other Vectorsp. 3
The Vector Systemp. 7
Developments in the Use of Adenovirus Recombinants as Vectorsp. 9
Adenoviral Recombinant Vectors: Applications to Basic Neurosciencep. 39
Adenoviral Recombinant Vectors: Applications to Neurological Gene Therapyp. 44
Immune Responses to Recombinant Adenoviral Vectors Delivered into the Brainp. 46
Summary: Targeting the Brain with Adenovirus-Derived Vectorsp. 48
Referencesp. 52
Adeno-Associated Viral Vectors
Biology of Adeno-Associated Virus and Its Recombinant Vectorsp. 65
AAV Vector Productionp. 74
Recombinant AAV-Mediated Transduction in the CNSp. 77
Factors Limiting Efficient Transductionp. 82
New Vectorsp. 86
Regulation of Transgene Expressionp. 87
Biosafetyp. 88
Referencesp. 90
Problems in the Use of Herpes Simplex Virus as a Vector
Introductionp. 99
General Aspects of Lytic Cycle Replication and Latent Infections of Neurons in Vivop. 100
Reducing Cytotoxicity of the Virus: The Gene Deletion Approachp. 102
Reducing Cytotoxicity of the Virus: The Amplicon Approachp. 103
The Problem of Long-Term Expression during HSV Latencyp. 104
Referencesp. 106
Lentiviral Vectors
Introductionp. 111
Lentiviral Vectorsp. 111
Direct Injection of Lentiviral Vectorsp. 114
Ex Vivo Gene Transfer Using Lentiviral Vectorsp. 115
Concluding Remarksp. 118
Referencesp. 119
Retroviral Vectors for Gene Delivery to Neural Precursor Cells
Introductionp. 123
Overview of Retrovirusp. 124
Generation of Recombinant Retroviral Vectorsp. 130
Gene Delivery to the Nervous System by Retroviral Vectorsp. 138
Referencesp. 145
Gene Therapy with Virus Vectors for Specific Diseases of the Nervous System
The Principles of Molecular Therapies for Glioblastoma
Introductionp. 151
Reviewp. 151
Referencesp. 158
Oncolytic Herpes Simplex Virus for Tumor Therapy
Introductionp. 165
Advantages of Oncolytic Cancer Therapyp. 167
Advantages of HSV as on Oncolytic Agentp. 167
Attenuation of HSV to Provide Tumor-Selective Replicationp. 168
Effects of Preexisting Immunity to HSVp. 171
Effects of the Immune Response in Enhancing Tumor Therapyp. 171
Clinical Experience with Oncolytic HSVp. 172
Improving Oncolytic HSVp. 173
Conclusionsp. 177
Referencesp. 178
Recombinant Retrovirus Vectors for Treatment of Malignant Brain Tumors
Introductionp. 185
Properties of Retrovirus Vectors and Virus Producer Cellsp. 186
RV-Mediated Brain Tumor Therapy in Animal Modelsp. 189
Clinical Studies with RV Vectorsp. 191
Conclusionsp. 197
Referencesp. 198
Adeno-Associated Viral Vectors for Parkinson's Disease
Introductionp. 205
Recombinant Adeno-Associated Viral Vectorp. 206
Restoration of DA Synthesis in the Striatump. 207
Neuroprotection by GDNF Gene Deliveryp. 213
Conclusionsp. 216
Referencesp. 218
Herpes Simplex Virus Vectors for Parkinson's Disease
Introductionp. 223
Gene Therapy and Parkinson's Diseasep. 224
Therapeutic Genes for Parkinson's Diseasep. 224
Genetics of Parkinson's Diseasep. 226
Gene Delivery to the Nervous Systemp. 228
HSV as a Vectorp. 228
HSV as a Vector for Parkinson's Diseasep. 235
Conclusionp. 237
Referencesp. 238
Gene Therapy for Stroke
Introductionp. 243
Neurotrophic Factorsp. 244
Application of Neurotrophic Factorsp. 249
Gene Therapyp. 253
Stem Cellsp. 259
Referencesp. 263
Gene Therapy for Mucopolysaccharidosis
Definition and General Considerations on Lysosomal Storage Diseasesp. 271
Addressing Lysosomal Enzymes to the Lysosomes: Enzyme Replacement Therapyp. 273
Mucopolysaccharidosisp. 277
Animal Models for Mucopolysaccharidosisp. 278
Treatment Strategies for Mucopolysaccharidosisp. 279
Perspectivesp. 288
Referencesp. 289
Indexp. 297
Contents of Recent Volumesp. 319
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780123668561
ISBN-10: 0123668565
Series: International Review of Neurobiology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 329
Published: 22nd August 2003
Publisher: ACADEMIC PR INC
Country of Publication: US
Dimensions (cm): 23.37 x 15.19  x 2.01
Weight (kg): 0.67

Earn 354 Qantas Points
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