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Integrated Biomaterials Science - Rolando Barbucci

Integrated Biomaterials Science

By: Rolando Barbucci (Editor)

Hardcover Published: 31st October 2002
ISBN: 9780306466786
Number Of Pages: 1037

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Integrated Biomaterials Science provides an intriguing insight into the world of biomaterials. It explores the materials and technology which have brought advances in new biomaterials, highlighting the way in which modern biology and medicine are synergistically linked to other key scientific disciplines-physics, chemistry, and engineering. In doing so, Integrated Biomaterials Science contains chapters on tissue engineering and gene therapy, standards and parameters of biomaterials, applications and interactions within the industrial world, as well as potential aspects of patent regulations.
Integrated Biomaterials Science serves as a comprehensive guide to understanding this dynamic field, yet is designed so that chapters may be read and understood independently, depending on the needs of the reader. Integrated Biomaterials Science is attractive to a broad audience interested in a deeper understanding of this evolving field, and serves as a key resource for researchers and students of biomaterials courses, providing all with an opportunity to probe further.
Key Features:

-Comprehensively covers the latest developments in the field,
-Each chapter is written by key field leaders,
-Covers applications and interactions within the industrial world,
-Presents standards on biomaterials,
-Explores aspects of patent regulations and patentability of biomaterials,
-Exceptionally detailed, yet easily understood - perfect as a guide for professional researchers or as a text for emerging students.

Biological Materials
Introductionp. 1
Fundamentals of Biological Materialsp. 2
Medical Application of Biological Materialsp. 14
Conclusionsp. 22
Referencesp. 22
Structure and Properties of Polymeric Materials
Introductionp. 25
Polymersp. 27
Polymers in Medicinep. 36
Requirements and Evaluation of Polymeric Materialsp. 43
Referencesp. 66
Fundamentals of Polymeric Composite Materials
Introductionp. 69
Fiber Reinforcementsp. 71
Matrix Resinsp. 78
Fiber/Matrix Adhesionp. 84
Volume and Weight Fractionsp. 87
Mechanics of Continuous-Fiber-Reinforced Compositesp. 88
Mechanics of Discontinuous-Fiber-Reinforced Compositesp. 99
Mechanics of Particulate Compositesp. 106
Manufacture of Compositesp. 108
Referencesp. 114
Biodegradable Polymers
Introductionp. 119
Definitionp. 120
Mechanismsp. 121
Properties and Applicationsp. 126
Natural Polymersp. 129
Synthetic Polymersp. 145
Factors Affecting the Degradation of Polymeric Materialsp. 165
Referencesp. 170
Bioceramics and Biological Glasses
The Structure of Ceramics from Synthesis to Processingp. 189
Design and Duration of Ceramic Devices under Loadp. 207
Ceramics for Surgical Implantsp. 208
A Survey on the Adhesion of Ceramics to Bone Tissuep. 252
Referencesp. 252
Metallic Materials
The Crystalline Structure of Metallic Materialsp. 255
Lattice Defectsp. 256
Structure of Metallic Alloysp. 262
Phase Diagramsp. 263
Thermal Treatmentsp. 272
Strengthening of Metalsp. 277
Working Technologiesp. 280
Main Metallic Materials Used as Biomaterialsp. 289
Degradation Processes on Metallic Surfaces
Introductionp. 297
The Biological Environmentp. 297
Metallic Corrosionp. 298
Corrosion Formsp. 308
Corrosion Preventionp. 320
Referencesp. 323
Characterization of Biomaterials
Requirements of Biomedical Characterizationp. 325
Structure of Materialsp. 327
The Nature of Surface Dynamics and Surface Analysisp. 328
Organization of Polymer Surfacesp. 330
Referencesp. 336
Tissues
Introductionp. 339
Soft Tissuesp. 340
Hard Tissuesp. 342
Referencesp. 345
Soft Tissue
Structure-Property Relationship of Soft Tissuep. 347
Skinp. 353
Tendons and Ligamentsp. 357
Referencesp. 363
The Eye
Introductionp. 367
The Corneap. 368
The Sclerap. 373
The Vitreousp. 375
Referencesp. 379
Articular Cartilage
Introductionp. 381
Composition and Structurep. 382
Mechanical Propertiesp. 386
Electromechanical Transductionp. 394
Remodeling and Repairp. 396
Referencesp. 398
The Mechanical and Material Properties of the Healthy and Degenerated Intervertebral Disc
Introductionp. 403
Anatomyp. 404
Material Properties of the Structures of the Discp. 406
Mechanical Behavior of the Intervertebral Discp. 411
The Effect of Degradation on the Mechanical Properties of the Discp. 415
Intervertebral Disc Prosthesesp. 416
Summaryp. 419
Referencesp. 420
Soft Tissue Replacement
Introductionp. 425
Cardiovascular Devicesp. 426
Intraocular Devicesp. 436
Other Applications in Soft Tissue Replacementp. 444
Conclusionsp. 449
Referencesp. 450
Mechanics of Hard Tissues
Introductionp. 459
Experimental Methods and Results: Determination of Mechanical Properties and Structural Configurationp. 462
Mechanics of Bonep. 469
Bone Physiologyp. 475
Functional Adaptation of Bonep. 476
Numerical Approachp. 482
Conclusionsp. 486
Referencesp. 486
Hip Joint Replacements
Introduction to Joint Replacementsp. 491
Historyp. 492
Cemented Prosthesesp. 498
The Noncemented Prosthesesp. 505
Friction and Wearp. 517
Referencesp. 520
Knee Joint Replacements
Introductionp. 527
Historyp. 529
The Knee: Anatomical, Functional, and Structural Considerationsp. 536
Polyethylenep. 537
Alignmentp. 545
Fixationp. 546
Patellofemoral Jointp. 547
Conclusionp. 550
Referencesp. 550
Biomaterial Applications: Elbow Prosthesis
Introductionp. 555
The Prosthetic Designp. 556
Cases in which the Elbow Prosthesis Is Advisablep. 558
Referencesp. 558
Biomaterial Applications: Shoulder Prosthesis
Introductionp. 561
The Prosthetic Designp. 562
The Prosthetic Implantationp. 563
Conforming Design of the Articular Surfacesp. 564
Articular and Periarticular Resistancesp. 566
The Active Role of Periarticular Musclesp. 566
Referencesp. 568
Acrylic Bone Cements
Introductionp. 569
Chemistry of Acrylic Bone Cementsp. 570
Mechanical Propertiesp. 574
Factors Affecting the Microstructure and the Microstructure-Mechanical Properties Relationshipp. 578
Biological Propertiesp. 582
Modification of Acrylic Bone Cementsp. 582
Referencesp. 584
Mechanical Properties of Tooth Structures
Introductionp. 589
Mechanical Propertiesp. 592
Referencesp. 597
Dental Materials and Implants
Introductionp. 601
Stomatognatic Apparatus: Some Considerationsp. 602
Dental Materials for Hard and Plastic Restorative Treatmentp. 609
Materials for Complex Reconstructionsp. 621
Prosthetic Therapy Materialsp. 622
Dental Implant Materials: A Few Considerationsp. 629
Biomaterials for Surgical Reconstitutionp. 631
Dental Implants and Biomechanicsp. 639
Referencesp. 647
Materials/Biological Environment Interactions
Introductionp. 655
Cell-Extracellular Matrix Interactionsp. 656
Growth Factors-Extracellular Matrix Interactionsp. 658
Extracellular/Biomaterial Interactionp. 659
Future Perspectivesp. 665
Referencesp. 666
Protein Adsorption and Cellular/Tissue Interactions
Introductionp. 669
Protein Adsorptionp. 670
Cells/Tissue Interactionsp. 678
Referencesp. 685
Inflammatory Response to Polymeric Materials
Introductionp. 691
Polymeric Materials in Contact with Living Tissuesp. 692
Characteristics of the Materials Involved in the Inflammatory Responsep. 696
Assessing the Inflammatory Response to Materialsp. 705
Conclusionp. 719
Abbreviations Used in this Chapterp. 723
Referencesp. 725
Inflammatory Response to Metals and Ceramics
Introductionp. 735
Materials Degradation and Inflammationp. 735
Acute Inflammatory Responsep. 741
Chronic Inflammationp. 760
Toxicity of Biomaterials and Inflammationp. 767
Specific Immune Responsep. 770
Referencesp. 780
Biocompatibility and Biological Tests
Definitionp. 793
Biocompatibility Tests and Their Rulesp. 795
Biological Testsp. 796
Biofunctionality Testsp. 810
Referencesp. 812
Infection and Sterilization
Infectionp. 815
Sterilizationp. 822
Referencesp. 829
Drug Delivery Systems
Introductionp. 833
Controlled or Programmable Drug Release versus Slow or Sustained Releasep. 834
Biodegradable and Nonbiodegradable Polymersp. 836
Polymers for Controlled Release Applicationsp. 837
Novel Drug Delivery System Preparationsp. 849
Internally or Externally Controlled Drug Delivery Systemsp. 853
Transdermal Therapeutic Delivery Systemsp. 859
Mechanisms of Drug Releasep. 864
Overviews of Problems Involving Long-Term Contact between Tissues and Drug Delivery Systemsp. 870
Referencesp. 872
Gene Delivery as a New Therapeutic Approach
Introductionp. 875
Different Kinds of Therapeutic Nucleic Acidsp. 876
Viral Vectorsp. 877
Synthetic Vectorsp. 877
Clinical Applications of Gene Transferp. 881
Referencesp. 882
Tissue Engineering
Introductionp. 885
Cell Culture and In Vitro Tissue Developmentp. 888
Artificial Skinp. 900
Artificial Cartilagep. 907
Artificial Bonep. 916
Glandular Parenchyma: The Liverp. 925
Referencesp. 936
Assist Devices
Introductionp. 947
Biomaterials Used in Extracorporeal Blood Processingp. 949
Artificial Devicesp. 950
Bioartificial Devicesp. 976
Suggested Readingp. 983
Nomenclaturep. 984
Standards on Biomaterials
Introductionp. 985
ISO Standards and Overviewp. 989
European Systemp. 992
Bibliographyp. 1002
Biomaterials and Patents
Introductionp. 1003
Patentable Inventionsp. 1009
Patentability of Biomaterialsp. 1012
Bibliographyp. 1013
Indexp. 1015
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780306466786
ISBN-10: 0306466783
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 1037
Published: 31st October 2002
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 5.08
Weight (kg): 1.92