Integrated Biomaterials Science

By: Rolando Barbucci

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Hardcover | 31 October 2002

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1072 Pages

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23.5 x 16.51 x 5.08

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Integrated Biomaterials Science provides an intriguing insight into the world of biomaterials. It explores the materials and technology which have brought advances in new biomaterials, highlighting the way in which modern biology and medicine are synergistically linked to other key scientific disciplines-physics, chemistry, and engineering. In doing so, Integrated Biomaterials Science contains chapters on tissue engineering and gene therapy, standards and parameters of biomaterials, applications and interactions within the industrial world, as well as potential aspects of patent regulations.
Integrated Biomaterials Science serves as a comprehensive guide to understanding this dynamic field, yet is designed so that chapters may be read and understood independently, depending on the needs of the reader. Integrated Biomaterials Science is attractive to a broad audience interested in a deeper understanding of this evolving field, and serves as a key resource for researchers and students of biomaterials courses, providing all with an opportunity to probe further.
Key Features:

-Comprehensively covers the latest developments in the field,
-Each chapter is written by key field leaders,
-Covers applications and interactions within the industrial world,
-Presents standards on biomaterials,
-Explores aspects of patent regulations and patentability of biomaterials,
-Exceptionally detailed, yet easily understood - perfect as a guide for professional researchers or as a text for emerging students.

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Biological Materials
Introduction	p. 1
Fundamentals of Biological Materials	p. 2
Medical Application of Biological Materials	p. 14
Conclusions	p. 22
References	p. 22
Structure and Properties of Polymeric Materials
Introduction	p. 25
Polymers	p. 27
Polymers in Medicine	p. 36
Requirements and Evaluation of Polymeric Materials	p. 43
References	p. 66
Fundamentals of Polymeric Composite Materials
Introduction	p. 69
Fiber Reinforcements	p. 71
Matrix Resins	p. 78
Fiber/Matrix Adhesion	p. 84
Volume and Weight Fractions	p. 87
Mechanics of Continuous-Fiber-Reinforced Composites	p. 88
Mechanics of Discontinuous-Fiber-Reinforced Composites	p. 99
Mechanics of Particulate Composites	p. 106
Manufacture of Composites	p. 108
References	p. 114
Biodegradable Polymers
Introduction	p. 119
Definition	p. 120
Mechanisms	p. 121
Properties and Applications	p. 126
Natural Polymers	p. 129
Synthetic Polymers	p. 145
Factors Affecting the Degradation of Polymeric Materials	p. 165
References	p. 170
Bioceramics and Biological Glasses
The Structure of Ceramics from Synthesis to Processing	p. 189
Design and Duration of Ceramic Devices under Load	p. 207
Ceramics for Surgical Implants	p. 208
A Survey on the Adhesion of Ceramics to Bone Tissue	p. 252
References	p. 252
Metallic Materials
The Crystalline Structure of Metallic Materials	p. 255
Lattice Defects	p. 256
Structure of Metallic Alloys	p. 262
Phase Diagrams	p. 263
Thermal Treatments	p. 272
Strengthening of Metals	p. 277
Working Technologies	p. 280
Main Metallic Materials Used as Biomaterials	p. 289
Degradation Processes on Metallic Surfaces
Introduction	p. 297
The Biological Environment	p. 297
Metallic Corrosion	p. 298
Corrosion Forms	p. 308
Corrosion Prevention	p. 320
References	p. 323
Characterization of Biomaterials
Requirements of Biomedical Characterization	p. 325
Structure of Materials	p. 327
The Nature of Surface Dynamics and Surface Analysis	p. 328
Organization of Polymer Surfaces	p. 330
References	p. 336
Tissues
Introduction	p. 339
Soft Tissues	p. 340
Hard Tissues	p. 342
References	p. 345
Soft Tissue
Structure-Property Relationship of Soft Tissue	p. 347
Skin	p. 353
Tendons and Ligaments	p. 357
References	p. 363
The Eye
Introduction	p. 367
The Cornea	p. 368
The Sclera	p. 373
The Vitreous	p. 375
References	p. 379
Articular Cartilage
Introduction	p. 381
Composition and Structure	p. 382
Mechanical Properties	p. 386
Electromechanical Transduction	p. 394
Remodeling and Repair	p. 396
References	p. 398
The Mechanical and Material Properties of the Healthy and Degenerated Intervertebral Disc
Introduction	p. 403
Anatomy	p. 404
Material Properties of the Structures of the Disc	p. 406
Mechanical Behavior of the Intervertebral Disc	p. 411
The Effect of Degradation on the Mechanical Properties of the Disc	p. 415
Intervertebral Disc Prostheses	p. 416
Summary	p. 419
References	p. 420
Soft Tissue Replacement
Introduction	p. 425
Cardiovascular Devices	p. 426
Intraocular Devices	p. 436
Other Applications in Soft Tissue Replacement	p. 444
Conclusions	p. 449
References	p. 450
Mechanics of Hard Tissues
Introduction	p. 459
Experimental Methods and Results: Determination of Mechanical Properties and Structural Configuration	p. 462
Mechanics of Bone	p. 469
Bone Physiology	p. 475
Functional Adaptation of Bone	p. 476
Numerical Approach	p. 482
Conclusions	p. 486
References	p. 486
Hip Joint Replacements
Introduction to Joint Replacements	p. 491
History	p. 492
Cemented Prostheses	p. 498
The Noncemented Prostheses	p. 505
Friction and Wear	p. 517
References	p. 520
Knee Joint Replacements
Introduction	p. 527
History	p. 529
The Knee: Anatomical, Functional, and Structural Considerations	p. 536
Polyethylene	p. 537
Alignment	p. 545
Fixation	p. 546
Patellofemoral Joint	p. 547
Conclusion	p. 550
References	p. 550
Biomaterial Applications: Elbow Prosthesis
Introduction	p. 555
The Prosthetic Design	p. 556
Cases in which the Elbow Prosthesis Is Advisable	p. 558
References	p. 558
Biomaterial Applications: Shoulder Prosthesis
Introduction	p. 561
The Prosthetic Design	p. 562
The Prosthetic Implantation	p. 563
Conforming Design of the Articular Surfaces	p. 564
Articular and Periarticular Resistances	p. 566
The Active Role of Periarticular Muscles	p. 566
References	p. 568
Acrylic Bone Cements
Introduction	p. 569
Chemistry of Acrylic Bone Cements	p. 570
Mechanical Properties	p. 574
Factors Affecting the Microstructure and the Microstructure-Mechanical Properties Relationship	p. 578
Biological Properties	p. 582
Modification of Acrylic Bone Cements	p. 582
References	p. 584
Mechanical Properties of Tooth Structures
Introduction	p. 589
Mechanical Properties	p. 592
References	p. 597
Dental Materials and Implants
Introduction	p. 601
Stomatognatic Apparatus: Some Considerations	p. 602
Dental Materials for Hard and Plastic Restorative Treatment	p. 609
Materials for Complex Reconstructions	p. 621
Prosthetic Therapy Materials	p. 622
Dental Implant Materials: A Few Considerations	p. 629
Biomaterials for Surgical Reconstitution	p. 631
Dental Implants and Biomechanics	p. 639
References	p. 647
Materials/Biological Environment Interactions
Introduction	p. 655
Cell-Extracellular Matrix Interactions	p. 656
Growth Factors-Extracellular Matrix Interactions	p. 658
Extracellular/Biomaterial Interaction	p. 659
Future Perspectives	p. 665
References	p. 666
Protein Adsorption and Cellular/Tissue Interactions
Introduction	p. 669
Protein Adsorption	p. 670
Cells/Tissue Interactions	p. 678
References	p. 685
Inflammatory Response to Polymeric Materials
Introduction	p. 691
Polymeric Materials in Contact with Living Tissues	p. 692
Characteristics of the Materials Involved in the Inflammatory Response	p. 696
Assessing the Inflammatory Response to Materials	p. 705
Conclusion	p. 719
Abbreviations Used in this Chapter	p. 723
References	p. 725
Inflammatory Response to Metals and Ceramics
Introduction	p. 735
Materials Degradation and Inflammation	p. 735
Acute Inflammatory Response	p. 741
Chronic Inflammation	p. 760
Toxicity of Biomaterials and Inflammation	p. 767
Specific Immune Response	p. 770
References	p. 780
Biocompatibility and Biological Tests
Definition	p. 793
Biocompatibility Tests and Their Rules	p. 795
Biological Tests	p. 796
Biofunctionality Tests	p. 810
References	p. 812
Infection and Sterilization
Infection	p. 815
Sterilization	p. 822
References	p. 829
Drug Delivery Systems
Introduction	p. 833
Controlled or Programmable Drug Release versus Slow or Sustained Release	p. 834
Biodegradable and Nonbiodegradable Polymers	p. 836
Polymers for Controlled Release Applications	p. 837
Novel Drug Delivery System Preparations	p. 849
Internally or Externally Controlled Drug Delivery Systems	p. 853
Transdermal Therapeutic Delivery Systems	p. 859
Mechanisms of Drug Release	p. 864
Overviews of Problems Involving Long-Term Contact between Tissues and Drug Delivery Systems	p. 870
References	p. 872
Gene Delivery as a New Therapeutic Approach
Introduction	p. 875
Different Kinds of Therapeutic Nucleic Acids	p. 876
Viral Vectors	p. 877
Synthetic Vectors	p. 877
Clinical Applications of Gene Transfer	p. 881
References	p. 882
Tissue Engineering
Introduction	p. 885
Cell Culture and In Vitro Tissue Development	p. 888
Artificial Skin	p. 900
Artificial Cartilage	p. 907
Artificial Bone	p. 916
Glandular Parenchyma: The Liver	p. 925
References	p. 936
Assist Devices
Introduction	p. 947
Biomaterials Used in Extracorporeal Blood Processing	p. 949
Artificial Devices	p. 950
Bioartificial Devices	p. 976
Suggested Reading	p. 983
Nomenclature	p. 984
Standards on Biomaterials
Introduction	p. 985
ISO Standards and Overview	p. 989
European System	p. 992
Bibliography	p. 1002
Biomaterials and Patents
Introduction	p. 1003
Patentable Inventions	p. 1009
Patentability of Biomaterials	p. 1012
Bibliography	p. 1013
Index	p. 1015
Table of Contents provided by Syndetics. All Rights Reserved.

Integrated Biomaterials Science

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

Other Editions and Formats

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