Innovative Concepts in Inflammatory Bowel Disease

By: J. Emmrich (Editor), S. Liebe (Editor), E.-F. Stange (Editor)

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Hardcover | 31 January 1999

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Hardcover
384 Pages

Dimensions(cm)
23.39 x 15.6 x 2.24

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Chronic inflammatory bowel diseases represent an important medical problem, since they have a devastating impact on the quality of life and require longstanding medical care. Many medical disciplines are involved in tackling the immensely complex studies on pathogenesis, clinical expression and treatment possibilities. This book, the proceedings of the Falk Symposium 105 on `Innovative Concepts in Inflammatory Bowel Diseases', held in Rostock, Germany, on April 30 - May 2, 1998, brought together experts from different fields of science to allow a unified view on clinical and basic research.
The main themes of the meeting were genetics, animal models, immunology, epithelial cells, endotoxin, diagnostic procedures, malignancy, medical therapies, and surgery. In each section of the book experts present state-of-the-art reviews with the very latest developments in the respective research areas followed by chapters on different aspects of inflammatory bowel diseases. They provide suggestions concerning future research and clinical management of patients with inflammatory bowel diseases.

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Gastroenterology Diseases & Disorders

List of Principal Authors	p. ix
Preface	p. xiii
IBD and Genetics
Relevant genes in IBD	p. 3
Epidemiological aspects of IBD	p. 15
HLA-antigens in IBD	p. 20
Autoantibodies in IBD	p. 27
Experimental Models of IBD
Experimental models of IBD: old hypotheses confirmed and new paradigms generated	p. 35
Neuroimmune interactions in IBD	p. 43
Interleukin-12 and anti-interleukin-12	p. 47
Spontaneous colitis and gastritis in HLA-B27/[beta subscript 2]-microglobulin transgenic rats and its association with normal luminal bacteria	p. 52
Basic Concepts of Mucosal Immunology
Mucosal immune system: an overview	p. 63
Effector mechanisms in intestinal immunity and inflammation	p. 74
Homing of mucosally activated lymphocytes in humans	p. 84
Principles of oral tolerance	p. 90
Immunological tolerance in IBD	p. 100
IBD and Immunology
Intestinal macrophages	p. 111
Role of fibroblasts in inflammatory bowel disease	p. 120
The role of extracellular matrix proteins in IBD	p. 129
Heat shock proteins in IBD	p. 136
Regulation and function of eosinophils and mast cells: implications for the gastrointestinal tract	p. 143
Epithelial Barrier in IBD
Role of epithelial cells in IBD	p. 155
Cytokines and intestinal epithelial cells	p. 173
Gastrointestinal permeability in Crohn's disease -- clinical relevance	p. 183
Injury and healing in the epithelium	p. 188
Endotoxin and IBD
Detection of endotoxin in IBD	p. 199
Diagnosis of IBD
Radiological investigation of IBD	p. 219
The pancreas in Crohn's disease	p. 228
Colonoscopy and laparoscopy in Crohn's disease in children	p. 233
IBD and Malignancy
IBD: intestinal cancer risk and surveillance	p. 239
Role of flow cytometry in surveillance strategies in patients with ulcerative colitis	p. 243
K-ras and p53 mutations in colonic lavage fluid of patients with long-standing IBD	p. 254
The impact of therapy on colorectal cancer in ulcerative colitis	p. 261
Therapy in IBD
Therapeutic concepts in IBD	p. 267
Salicylates	p. 276
Glucocorticosteroids in the treatment of IBD	p. 289
Immunosuppressive therapy	p. 297
Monoclonal antibodies and interleukins	p. 304
Antibiotic therapy in Crohn's disease	p. 311
Alternative therapeutic approaches in IBD	p. 317
Endoscopic therapy	p. 328
Surgical therapy of Crohn's disease	p. 333
Surgical therapy in ulcerative colitis with special reference to restorative proctocolectomy	p. 339
Index	p. 351
Table of Contents provided by Syndetics. All Rights Reserved.

Innovative Concepts in Inflammatory Bowel Disease

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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