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Inflammatory Bowel Disease : from Bench to Bedside - Stephan R. Targan

Inflammatory Bowel Disease

from Bench to Bedside

By: Stephan R. Targan (Editor), Fergus Shanahan (Editor), Loren C. Karp (Editor)

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This book is intended to be more than a comprehensive compilation of reviews by individual authors on different aspects of inflammatory bowel diseases. It is intended that the individual chapters be components of a coherent, albeit detailed, story of the local and systemic pathophysiology of intestinal inflammation, with a well-reasoned series of management strategies. Our goal was not only to produce a standard reference text, but also to present research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders. Our vision was to have a book that would blend recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease. It is our hope that the book will illustrate the effectiveness of a team approach of basic scientists and clinician investigators in this field. The book will give the reader a glimpse of where the field is moving and an idea of likely research directions in the future. Of course, it is our personal wish that this book will stimulate ideas for future research.

'This is one of the most comprehensive, well written and convincing books on IBD we have had the opportunity to examine in recent years. It is well written (it includes several well known experts in the field), nicely illustrated, up to date (references reach up to 2001) and extremely stimulating. If you have EUR 200 to invest, do not hesitate to buy this book: you will be well rewarded by all you will learn when you glance through its pages.' Digestive and Liver Disease, 36 (2004)

Prefacep. v
The laboratory bench
Introduction: Inflammatory bowel diseases: from bench to bedsidep. 3
The changing faces of Crohn's disease and ulcerative colitisp. 5
Genetics of inflammatory bowel diseasep. 21
Experimental mouse models of inflammatory bowel disease: new insights into pathogenic mechanismsp. 67
The normal intestinal mucosa: a state of 'controlled inflammation'p. 101
The lymphocyte-epithelial-bacterial interfacep. 121
The mucosal inflammatory response. Cytokines and chemokinesp. 147
Role of the microcirculation in chronic gut inflammationp. 177
Remission, relapse, intestinal healing and repairp. 197
Antibodies in the exploration of inflammatory bowel disease pathogenesis and disease stratificationp. 211
Pathophysiology of inflammatory bowel disease: the effect of inflammation on intestinal functionp. 223
Systemic consequences of intestinal inflammationp. 235
The bedside
Understanding symptoms and signs in inflammatory bowel diseasep. 253
Clinical course and complications of ulcerative colitis and ulcerative proctitisp. 269
Clinical features and complications of Crohn's diseasep. 291
Mechanisms of systemic inflammation associated with intestinal injuryp. 305
Pathology of inflammatory bowel diseases: a critical appraisal in diagnosis and managementp. 337
An endoscopic and histologic perspective of diagnosis: when, where, and what to dop. 357
Radiologic (radiographic) and imaging features of ulcerative colitis and Crohn's diseasep. 371
New diagnostic approaches in inflammatory bowel diseasep. 409
Differential diagnosis of colitisp. 431
'Disease management' in chronic medical conditionsp. 457
Pharmacoeconomics and inflammatory bowel diseasep. 471
Measuring quality of life in inflammatory bowel diseasep. 481
Clinical pharmacology in inflammatory bowel disease: optimizing current medical therapyp. 495
Multi-site therapeutic modalities for inflammatory bowel diseases - mechanisms of actionp. 523
Targeted therapies for inflammatory bowel diseasep. 553
Role of antibiotics and probiotics in the management of inflammatory bowel diseasep. 573
Nutrition in inflammatory bowel diseasep. 587
Medical management of ulcerative colitisp. 605
Surgical management of ulcerative colitisp. 631
Pouchitis: clinical characteristics and managementp. 643
Medical therapy for Crohn's diseasep. 659
Surgery for Crohn's diseasep. 681
Postoperative prevention of recurrence of Crohn's diseasep. 697
The molecular pathology of inflammatory bowel disease-associated neoplasia and preneoplasiap. 711
Dysplasia in inflammatory bowel disease: clinical pathology and current surveillance methodsp. 719
Hepatobiliary disordersp. 731
Articular and ocular complications of inflammatory bowel diseasep. 747
Cutaneous manifestations of inflammatory bowel diseasep. 757
Fertility and pregnancy in inflammatory bowel diseasep. 763
Special considerations in the diagnosis and management of inflammatory bowel disease in the pediatric age groupp. 773
Microscopic colitis: collagenous and lymphocytic colitisp. 791
Colon ischemiap. 799
Diversion colitisp. 811
Pseudomembranous colitis and Clostridium difficile infectionp. 823
Infectious colitisp. 845
Human immunodeficiency virus and inflammatory bowel diseasep. 863
Bone metabolism and inflammatory bowel diseasep. 875
Back to the laboratory bench
Epilogue: Bench to bedside and back to benchp. 887
Indexp. 893
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9781402007132
ISBN-10: 1402007132
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 903
Published: April 2003
Country of Publication: US
Dimensions (cm): 26.0 x 19.5  x 5.08
Weight (kg): 2.52
Edition Number: 2
Edition Type: Revised