Inflammation and Stroke : Pir - Progress in Inflammation Research - Giora Z. Feuerstein

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Inflammation and Stroke

By: Giora Z. Feuerstein (Editor)

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Hardcover | 1 December 2001

At a Glance

Hardcover
376 Pages

Dimensions(cm)
24.77 x 18.42 x 3.18

Hardcover

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Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events in brain ischemia. New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The recognition of inflammation as a fundamental response to brain ischemia provides novel opportunities for new anti-inflammatory therapies. For the first time, an international body of researchers presents the latest findings about the cellular and humoral aspects of immune and inflammatory reactions in the brain. The work may have an impact on the treatment of neuroinjuries and ancillary brain diseases, and increase the understanding of the roles infections and immune reactions play in the brain milieu.

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Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Other Branches of Medicine Pharmacology Neurology & Clinical Neurophysiology Medicine in General Medical Equipment & Techniques Medical Research Science Biology, Life Sciences

Pathology

List of contributors
Introduction
New opportunities for stroke prevention and therapeutics: a hope from anti-inflammatory drugs?	p. 3
Inflammation in stroke and CNS trauma - experimental and clinical evidence
Clinical evidence of inflammation as a risk factor in ischemic stroke	p. 13
Inflammation as a risk factor for stroke: evidence from experimental models	p. 27
Inflammatory and immune responses to CNS injury: beneficial and detrimental components
Salutary effect of autoimmune T cells after central nervous system injury	p. 37
Traumatic brain injury: is head trauma an inflammatory disease?	p. 49
Cyclic activation and inactivation of brain vessels involving inflammatory mediators - implications for stroke	p. 61
Inflammatory cells in stroke
Do leukocytes play a role in focal ischemia in the brain? A objective review of the literature	p. 77
The role of microglia in ischemic brain injury	p. 89
Inflammatory activation of brain cells by hypoxia: transcription factors and signaling pathways	p. 101
Inflammatory cytokines, interleukins and chemokines in stroke and CNS trauma
Cytokine effects on CNS cells: implications for the pathogenesis and prevention of stroke	p. 115
Interleukin-10 in cerebral ischemia and stroke	p. 141
Chemokines and ischemic stroke	p. 155
Biphasic activity of tumor necrosis factor in stroke and brain trauma: interaction with reactive oxygen species	p. 163
Interleukin-1 and IL-1 receptor antagonist in stroke: mechanisms and potential therapeutics	p. 173
Inflammatory cytokines in CNS trauma	p. 181
Inflammation in cerebral thrombosis, angiogenesis and matrix regulation: a new perspective in stroke research and therapeutics
Microvessel integrin expression during focal cerebral ischemia	p. 195
The inflammatory response in focal cerebral ischemia	p. 221
Chronic neuronal perturbation mediated by RAGE, a receptor for [beta]-sheet fibrils and S100/calgranulins	p. 241
Mediators of inflammation and blood-brain barrier permeability in cerebral ischemia	p. 253
Inflammatory proteases and oxygen radicals in stroke
The role of metalloproteinases on blood-brain barrier breakdown after ischemic stroke	p. 265
Matrix metalloproteinases and their inhibitors in hypoxia/reoxygenation and stroke	p. 275
Extracellular matrix-degrading metalloproteinases and neuroinflammation in stroke	p. 287
Anti-oxidant strategies to treat stroke	p. 299
Inflammatory adhesion molecules, kinins, nitric oxide complement factors and lipid mediators in stroke
Selectin- and complement-mediated mechanisms of tissue injury in stroke	p. 315
The kallikrein-kinin system in ischemic and traumatic brain injury	p. 333
Nitric oxide, nitric oxide synthases and cyclooxygenase-2 in experimental focal stroke	p. 343
Index	p. 351
Table of Contents provided by Blackwell. All Rights Reserved.

Inflammation and Stroke

At a Glance

Hardcover

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