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Induction and Modulation of Gastrointestinal Inflammation : Falk Symposium - A. Stallmach

Induction and Modulation of Gastrointestinal Inflammation

Falk Symposium

By: A. Stallmach (Editor), M. Zeitz (Editor), W. Strober (Editor), Thomas T. MacDonald (Editor), Herbert Lochs (Editor)

Hardcover Published: 31st December 1998
ISBN: 9780792387473
Number Of Pages: 330

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This book, the proceedings of Falk Symposium No. 104, organized in collaboration with the Society of Mucosal Immunology, and held in Saarbrucken, Germany, March 5-7 1998, is centered around the immunological mechanisms of mucosal protection and their disturbances leading to intestinal inflammation and destruction. This is a rapidly expanding field involving recent knowledge of basic immunology and cell biology as well as clinical observations. The conference and this book summarize very recent data in this field and suggest strategies for future research and clinical applications, and will be of interest to both basic scientists and clinicians.

List of Principal Authors
Preface
Molecular and functional characterization of M cells: targeting restriction, molecular markers, and effects of an intestinal inflammation model on rat M cellsp. 3
Lymphoepithelial interactions trigger M cell formation and permeability to microorganismsp. 18
Subsets of dendritic cells in the Peyer's patchp. 24
Antigen presentation by epithelial cellsp. 30
Functional role of FcRn on intestinal epithelial cellsp. 38
The intestinal epithelial cell proinflammatory programme: integral role of human intestinal epithelial cells in innate and acquired mucosal immunityp. 50
Finding the source: continuing controversies regarding the origin of intraepithelial lymphocytesp. 63
Local proliferation and apoptosis of T cell subsets versus homingp. 74
Mutant enterotoxins and cytokines for safe targeting of T[subscript H]1- and T[subscript H]2-type responses to mucosal vaccinesp. 81
Inflammatory bowel diseases: a breakdown of central and peripheral immunological homeostasisp. 97
Pathways of T cell pathology in models of experimental colitisp. 111
Murine colitis induced by adoptive transfer of immunocompetent CD4[superscript +] T cells into immunodeficient hostsp. 129
Biochemical characterization of CD4[superscript +], [alpha][superscript -][beta][superscript +] T cells in TCR-[alpha] mutant mice with inflammatory bowel diseasep. 142
The Inhibition of the CD40L-CD40 interaction prevents the intestinal manifestations of acute murine graft-versus-host diseasep. 147
Concepts in the treatment of experimental granulomatous colitis with Th1 inhibitory therapeutic modalitiesp. 156
TNF-induced matrix metalloproteinase production in gut inflammationp. 164
The role of bacterial flora in experimental models of intestinal inflammationp. 175
Role of normal intestinal florap. 184
Local regulatory mechanisms in Helicobacter pylori infectionp. 194
Immunodeficiency in Whipple's diseasep. 204
Interferon-[gamma] induces necrosis in the small intestines of mice following peroral infection with Toxoplasma gondiip. 209
Physiological role of apoptotic mechanisms in the gutp. 217
Shifting T[subscript H]1/T[subscript H]2 responses as therapeutic approachp. 225
TGF-[beta] mediated oral tolerancep. 231
Induction of immunological tolerance by antigen delivery via the colonp. 240
Immunological findings in inflammatory bowel diseasep. 243
Conventional drug therapy and immunomodulatory strategies in IBDp. 251
Antagonists of pro-inflammatory cytokinesp. 259
Mechanisms and clinical efficacy of interleukin-10p. 265
Interleukin-10 induces apoptosis of activated neutrophils via the nuclear factor kappa-Bp. 272
Additive and synergistic effects of T[subscript H]-2-cytokines in IBD: balance of proinflammatory and immunosuppressive mediatorsp. 274
Insensitivity towards inhibition by cyclosporin A, rapamycin and tacrolimus in human intestinal lamina propria T lymphocytesp. 289
Cyclosporin A resistant co-stimulatory signalling pathways in human T lymphocytesp. 297
Immunomodulation in experimentally induced colitis using chimeric interleukin-2 fusion proteinsp. 306
Anti-T cell strategiesp. 313
Indexp. 321
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792387473
ISBN-10: 0792387473
Series: Falk Symposium
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 330
Published: 31st December 1998
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 1.47

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