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Inducible Enzymes in the Inflammatory Response : Progress in Inflammation Research - Willoughby

Inducible Enzymes in the Inflammatory Response

By: Willoughby (Editor), Tomlinson (Editor)

Hardcover | 1 December 1998

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The inducible isoforms of the enzymes cyclooxygenase (COX 2), nitric oxide synthase (iNOS) & heme oxygenase 1 (HO-1) have generated great interest as possible therapeutic targets in inflammation. This book is the first publication to address the importance of all three enzymes & the consequences of their interactions to the inflammatory process. The book brings together overviews by leading researchers in the field of the current status of knowledge of COX, NOS & HO in inflammation. These overviews cover a series of new concepts in the mechanism of inflammation. Topics include: Inducible enzyme involvement in inflammatory processes including the role in vascular permeability, leukocyte migration, granuloma formation, angiogenesis, neuroinflammation & algesia. New findings from transgenic animal models are reviewed. Other chapters address the importance of these enzymes in inflammatory disease states including rheumatoid arthritis, atherosclerosis & multiple sclerosis. The possibility of selective inhibitors or inducers of COX, NOS & HO, & their use in the clinic is discussed.

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