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Induced Effects Of Genotoxic Agents In Eukaryotic Cells - Toby G. Rossman

Induced Effects Of Genotoxic Agents In Eukaryotic Cells

By: Toby G. Rossman (Editor)

Hardcover Published: 1st January 1992
ISBN: 9781560322726
Number Of Pages: 167

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Since 1980 there has been an accumulation of new information concerning DNA-damage-inducible processes in eukaryotic cells. It is clear that changes in the concentrations of activities of specific protein molecules play central roles in toxicological response of cells to chemical and radiation damage to DNA. Identification of inducible proteins may be crucial in helping to explain target organ toxicity and species differences. Detection of these proteins or their mRNA's in humans may be useful in assessing human exposure or cellular injury. Written by leading professionals who have extensive experience in the mutagenic/carcinogenic area, the aim of this monograph is to examine the responsiveness of eukaryotic cells to a variety of environmental toxicants. In particular, this text's ten chapters are devoted to the response seen at the molecular (gene, chromosome, DNA) level. The emphasis is placed on the toxic agents rather than the genetic process. It is aimed at toxicologists, specifically genetic toxicologists, radiation researchers and graduate students doing research in this area, and people dealing in risk assessment.

Contributors
Preface
Xenobiotic Regulation of Glutathione S-Transferase Ya Gene Expressionp. 1
Induction of a UV Damage-Specific DNA-Binding Protein Correlates with Enhanced DNA Repair in Primate Cellsp. 21
Repair of Alkylated Bases in Mammalian Cells: Modulation in Response to DNA-Damaging Agentsp. 39
Modifications in DNA Ligase Activity During DNA Repair in Mammalian Cellsp. 51
Cell-Cycle and DNA-Damage Regulation of Ribonucleotide Reductase in Saccharomyces cerevisiaep. 65
Review: Gene Amplification - A Cellular Response to Genotoxic Stressp. 81
Carcinogen-Inducible Proteins as Mediators of Asynchronous Replication of DNA Tumor Virusesp. 97
Carcinogen-Induced Gene Amplification and Gene Expressionp. 113
gadd153, a Growth Arrest and DNA Damage Inducible Gene: Expression in Response to Genotoxic Stressp. 125
Ultraviolet Irradiation and Phorbol Esters Induce Gene Transcription by Different Mechanismsp. 141
Index: Physical and Chemical Inducers and Inhibitorsp. 163
Index: Genetic Elements, Gene Products and Inducible Functioningp. 165
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9781560322726
ISBN-10: 1560322721
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 167
Published: 1st January 1992
Publisher: CRC PR INC
Country of Publication: US
Dimensions (cm): 26.37 x 18.19  x 1.58
Weight (kg): 0.55
Edition Number: 1