Induced Effects Of Genotoxic Agents In Eukaryotic Cells

By: Toby G Rossman (Editor)

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Hardcover | 21 September 1992 | Edition Number 1

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Hardcover
184 Pages

Dimensions(cm)
25.4 x 17.78 x 1.27

Hardcover

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Since 1980 there has been an accumulation of new information concerning DNA-damage-inducible processes in eukaryotic cells. It is clear that changes in the concentrations of activities of specific protein molecules play central roles in toxicological response of cells to chemical and radiation damage to DNA. Identification of inducible proteins may be crucial in helping to explain target organ toxicity and species differences. Detection of these proteins or their mRNA's in humans may be useful in assessing human exposure or cellular injury. Written by leading professionals who have extensive experience in the mutagenic/carcinogenic area, the aim of this monograph is to examine the responsiveness of eukaryotic cells to a variety of environmental toxicants. In particular, this text's ten chapters are devoted to the response seen at the molecular (gene, chromosome, DNA) level. The emphasis is placed on the toxic agents rather than the genetic process. It is aimed at toxicologists, specifically genetic toxicologists, radiation researchers and graduate students doing research in this area, and people dealing in risk assessment.

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