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Inclusion-Body Myositis and Myopathies - Valerie Askanas

Inclusion-Body Myositis and Myopathies

By: Valerie Askanas (Editor), Georges Serratrice (Editor), W. King Engel (Editor)

Hardcover Published: 13th April 1998
ISBN: 9780521571050
Number Of Pages: 413

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Inclusion-body myositis (IBM) is now understood to be an important degenerative muscle disease. The sporadic type (s-IBM) is probably the most common muscle disease among those ailments that strike first in adulthood (particularly people over 50). The hereditary type (h-IBM) affects younger patients. This book is devoted entirely to s-IBM and h-IBM. Contributors discuss what is understood about the basic scientific foundations of IBMs, the varied aspects of the pathology of IBMs, and the application of clinical treatments. One particular emphasis of the book is on the hereditary aspects of IBM and genetic predispositions to the disease.

' ... richly illustrated book which has been written by people who can be considered experts on the subject of sporadic inclusion body myositis (s-IBM) and hereditary inclusion body myopathy. The book is a must for all neuromyologists.' Neuromuscular Disorders

List of contributors
Preface
Newest Approaches to Diagnosis and Pathogenesis of Sporadic Inclusion-Body Myositis and Hereditary Inclusion-Body Myopathies, including Molecular-Pathologic Similarities to Alzheimer Diseasep. 3
Evolving Concepts of Inclusion-Body Myositisp. 81
Sporadic Inclusion-Body Myositis: Clinical and Laboratory Features and Diagnostic Criteriap. 107
Inclusion-Body Myositis: Natural Historyp. 116
Uncommon Clinicopathologic Forms of Sporadic Inclusion-Body Myositis: Report of 4 Casesp. 126
Inclusion-Body Myositis: Pathologic Changesp. 137
Unusual Pathologic Forms of Inclusion-Body Myositis and Neuromuscular Disorders with IBM-like Changesp. 156
Electrophysiologic Findings in Inclusion-Body Myositisp. 172
Genetic Factors in Sporadic Inclusion-Body Myositisp. 177
Hereditary Inclusion-Body Myopathy in Jews of Persian Origin: Clinical and Laboratory Datap. 191
Hereditary Inclusion-Body Myopathy with Quadriceps Sparing: Epidemiology and Geneticsp. 200
Familial Autosomal-Recessive Inclusion-Body Myositis with Asymptomatic Leukoencephalopathyp. 211
Welander Distal Myopathy: Clinical, Pathophysiologic, and Molecular Aspectsp. 221
Tibial Muscular Dystrophy: Clinical, Genetic, and Morphologic Characteristicsp. 232
Distal Myopathy with Rimmed Vacuoles, Inclusion-Body Myositis, and Related Disorders in Japanp. 244
Inclusion-Body Myopathiesp. 252
Muscle Fibers in IBM: Antigen-presenting Cells or Innocent Bystanders?p. 263
Viruses, Immunodeficiency, and Inclusion-Body Myositisp. 275
Myonuclear Abnormalities May Play a Central Role in the Pathogenesis of Muscle-Fiber Damage in Inclusion-Body Myositisp. 291
Nuclear Degeneration and Rimmed-Vacuole Formation in Neuromuscular Disordersp. 297
Mitochondrial Alterations in Sporadic Inclusion-Body Myositisp. 306
Mitochondrial DNA Analysis in Muscle of Patients with Sporadic Inclusion-Body Myositis and Hereditary Inclusion-Body Myopathyp. 318
Evaluation of Treatment for Sporadic Inclusion-Body Myositisp. 331
Treatment of Inclusion-Body Myositis and Hereditary Inclusion-Body Myopathy with Reference to Pathogenic Mechanisms: Personal Experiencep. 351
Indexp. 383
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780521571050
ISBN-10: 0521571057
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 413
Published: 13th April 1998
Publisher: Cambridge University Press
Country of Publication: GB
Dimensions (cm): 22.8 x 15.2  x 2.3
Weight (kg): 0.73