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In Vitro Neurotoxicology : Principles and Challenges - Evelyn Tiffany-Castiglioni

In Vitro Neurotoxicology

Principles and Challenges

Hardcover Published: 1st December 2003
ISBN: 9781588290472
Number Of Pages: 331

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Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.

"This book covers a wide range of topics, starting with a nice overview of the field of neurotoxicology. Moving on to the meat of the material, the effects of toxins on neural development, function, and degeneration are examined, using well studied neurotoxicants as examples. A thorough list of articles as well as an annotated reading list are valuable additions, making the book an excellent reference. This is a valuable reference for anyone studying the advances in neurotoxicology. It is concise and easy to comprehend, without sacrificing quality in the process. It is written by leaders in the field, ensuring the information is relevant and up-to-date."-Doody's Health Sciences Book Review Journal

"This is a useful book that updates new an improved in vitro methods to help further understanding neurotoxicology. The information presented is exciting, the methods proposed are often innovative, and readers will find a challenging glimpse into the future contributions their own research efforts can generate. Neurotoxicologists will find studying this volume rewarding and inspiring." - Vet Human Toxicol

"...a helpful and up to date book..." - BTS Newsletter

Dedicationp. v
Forewordp. vii
Prefacep. ix
Contributorsp. xiii
In Vitro Neurotoxicology: Introduction to Conceptsp. 1
Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessmentp. 29
Exposure--Dose--Response Paradigm as It Relates to Toxicogenomicsp. 41
In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasisp. 59
Role of Apoptosis in Neurotoxicologyp. 95
Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants: Enzyme Pathways in Neurons and Astrogliap. 133
Cell-Type-Specific Responses of the Nervous System to Leadp. 151
Effects of Toxicants on Neural Differentiationp. 187
Impairment of Synaptic Function by Exposure to Leadp. 217
Aggregating Brain Cell Cultures for Neurotoxicological Studiesp. 243
Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptorsp. 267
Establishing In Vitro Models to Study Endogenous Neurotoxicantsp. 291
Annotated Reading Listp. 315
Indexp. 325
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9781588290472
ISBN-10: 1588290476
Series: Methods in Pharmacology and Toxicology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 331
Published: 1st December 2003
Country of Publication: US
Dimensions (cm): 23.22 x 15.55  x 2.46
Weight (kg): 0.71
Edition Type: Annotated