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In Situ Hybridization : Medical Applications - G. R. Coulton

In Situ Hybridization

Medical Applications

By: G. R. Coulton (Editor), J. De Belleroche (Editor)

Hardcover

Published: 31st May 1992
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In situ hybridization has developed as a means of localizing specific DNA and RNA sequences within tissues. The great strength of this approach is the ability to relate the distribution of specific nucleic acids with cell structures and the protein products of the target gene by means of immunohistochemistry. Complementary DNA, RNA or oligonucleotide probes, suitably labelled, are hybridized to specific DNA or RNA targets within tissues. The spatial information thus obtained has contributed greatly to our understanding of such diverse areas of research as gene mapping, viral infection, cytogenetics, protein synthesis, prenatal diagnosis and tissue grafting.
This book is not intended as another recipe book, although it does describe theoretical and practical aspects of the technology. Rather, the authors critically describe the contribution made by in situ hybridization to specific areas of medical research.

List of contributors
Preface
Colour plates
Techniques for in situ hybridization histochemistryp. 1
Use of comparative in situ hybridization and immunocytochemistry for the study of regulatory peptidesp. 37
Application of in situ hybridization to studies of messenger RNA in the nervous system: functional correlations and their quantitationp. 52
The use of in situ hybridization in studies of viral diseasep. 66
In situ hybridization for molecular cytogeneticsp. 97
Indexp. 111
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792389897
ISBN-10: 0792389891
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 116
Published: 31st May 1992
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 24.13 x 16.51  x 1.27
Weight (kg): 0.39