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Immunotoxicology and Risk Assessment - Dennis K. Flaherty

Immunotoxicology and Risk Assessment

Hardcover Published: January 1999
ISBN: 9780306459719
Number Of Pages: 382

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This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on hazard identification, appropriate assays, dose response, and risk assessment by mathematical models and safety factors. It will be a useful reference to toxicologists because it will incorporate new guidelines that the EPA is bringing out later this year for all chemicals regulated under the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. Regulatory sections in each chapter focus on data from both the US Food and Drug Administration, as well as data applicable to western European Nations.

Introduction to Immunotoxicologyp. 1
Innate Immunityp. 7
Cells of the Immune Systemp. 15
Immunogenicity and Antigenicityp. 39
Antigen-Presenting Cellsp. 50
Antigen Presentationp. 57
Surface Interactions and Intracellular Signalingp. 71
B-Cell Activationp. 89
Antibodiesp. 99
Immunological Memoryp. 117
Complementp. 123
Phagocytosis and Intracellular Killingp. 139
Immediate Hypersensitivity Reactionsp. 155
Autoimmunityp. 173
Delayed Hypersensitivity Reactionsp. 187
Killer Cellsp. 197
Killer Cells and Viral Infectionsp. 211
Transplantationp. 219
The Kinesp. 229
Assessment of Biological Significance: Host Defense and Tumor Modelsp. 247
Risk Characterizationp. 271
Referencesp. 283
Indexp. 371
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306459719
ISBN-10: 030645971X
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 382
Published: January 1999
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 22.86 x 15.24  x 2.54
Weight (kg): 0.75