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Immunopharmacology in Autoimmune Diseases and Transplantation - L. Endresen

Immunopharmacology in Autoimmune Diseases and Transplantation

By: L. Endresen (Editor), O. Forre (Editor), Hans Erik Rugstad (Editor)

Hardcover

Published: 31st December 1992
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This book incorporates the latest advances in immunopharmacological treatment. One objective has been to provide appropriate bridges between the basic sciences of immunology and pharmacology on the one hand and clinical medicine on the other. A further intention has been to emphasize those advances in immunology and pharmacology that are of clinical importance while retaining those facts that, while not new, remain clinically useful. The immunology section provides the necessary background for immunopharmacologi- cal treatment. The chapters on individual cell types include normal surface markers, mode of activation, and activation markers and functions in health and disease. The chapters on pharmacology give comprehensive information on immunosuppressive drugs in regular use today, their biochemical and cellular mechanisms of action, pharmaco- kinetics, dosage regimens, therapeutic responses, adverse reactions, and drug interactions and tolerance. In addition, certain therapeutic principles that are still in an experimental phase are described, for example, immunotoxins, thymic hormones, and interleukins. The book presents comprehensive information on various autoimmune diseases, the etiopathogenetic immune mechanisms where these are known, and the current possibilities for immunopharmacological intervention. The specific disease section also covers rare situations, fluctuations in disease patterns, and subgroups of patients and immunophar- macological treatment in these situations. Altogether, the book represents a practical textbook for clinicians and advanced students who want to be updated on therapeutic principles with regard to autoimmune diseases and transplantation.

Immunology and Pathogenetic Mechanisms
Human Immune Response Genes
Accessory Cells
B Cells in Autoimmunity
T Lymphocytes in Autoimmunity and Transplantation
Natural Killer Cells in Autoimmune Diseases: Function and Markers
Interleukins: Molecular and Biological Properties
The Immunologic Network: Possibilities for a New Immunopharmacology
Pharmacology and General Therapeutic Principles of Immunomodulating Drugs
Steroids
Mode of Action of Thiopurines: Azathioprine and 6-Mercaptopurine
Pharmacology and General Therapeutic Principles of Methotrexate
Alkylating Agents
Cyclosporin A: Pharmacology and Therapeutic Use in Autoimmune Diseases
Nonsteroidal and Other Anti-inflammatory Drugs
Anti-T-Cell Monoclonal Antibodies as Immunosuppressive Agents
Immunotoxins
Interferons, Thymic Hormones, and Interleukins
Strategy in Immunosuppression
Immunosuppressive Drugs: The Need for Therapeutic Drug Monitoring
Immunopharmacological Treatment during Pregnancy and Lactation
Immunotherapy in Autoimmune Disease
Systemic Lupus Erythematosus and Related Syndromes
Immunopharmacology of Vasculitic Syndromes
Immunotherapy in Autoimmune Liver Disease
Insulin-Dependent Diabetes Mellitus
Immunoregulatory Treatment in Inflammatory Bowel Disease
Disorders of Neuromuscular Transmission
Immune Therapy for Autoimmune Uveitis
Cyclosporine A in the Treatment of Dermatologic Diseases
Immunotherapy in Kidney Diseases
Mechanisms Involved in Immunomodulatory Treatment of Rheumatoid Arthritis
Immunotherapy in Organ and Bone Marrow Transplantation
Immunotherapy in Organ Transplantation
Bone Marrow Transplantation
Index
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306439940
ISBN-10: 0306439948
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 420
Published: 31st December 1992
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.15  x 3.18
Weight (kg): 0.98