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Immunology of Liver Disease : Immunology and Medicine - H.C. Thomas

Immunology of Liver Disease

Immunology and Medicine

By: H.C. Thomas (Editor), J. Waters (Editor)

Hardcover Published: 31st December 1993
ISBN: 9780792389750
Number Of Pages: 209

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The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. This book aims to present the current understanding of the involvement of the immune response in liver disease. The first chapters examine the role of the immune response in viral infections of the liver. These viruses cause hepatitis of varying severity and it is thought that many of the mechanisms responsible for liver cell injury are immunologically mediated. In addition three of these viruses, hepatitic B, C, and D, are associated with persistent infection and chronic liver disease. The role of the immune response in viral persistence is discussed. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue. There has been much recent research on cellular immune responses in these diseases but knowledge of the immunological processes which lead to the breakdown of tolerance and the mechanisms of tissue damage are limited. Other research has concentrated on the identification of the antigens which are the targets of this immune response. Linkage disequilibrium between MHC alleles and autoimmune diseases has suggested a role for immunogenetic factors.

Series Editor's Note
List of Contributors
Immunopathology and virus infectionsp. 1
Immunopathology of hepatitis A and hepatitis E virus infectionsp. 11
Immunopathology of hepatitis B and D virus infectionsp. 39
Hepatitis C virus: infection and immunityp. 57
Human hepatoma associated antigens: Opportunities for immunotherapyp. 69
Mechanisms of autoimmunityp. 85
Autoantibodies and their cytoplasmic antigens in autoimmune chronic active hepatitisp. 111
Primary biliary cirrhosisp. 121
The immunology of primary sclerosing cholangitisp. 145
Immune mechanisms in alcoholic liver diseasep. 157
Immune-mediated drug hepatotoxicityp. 173
Indexp. 201
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792389750
ISBN-10: 0792389751
Series: Immunology and Medicine
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 209
Published: 31st December 1993
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 1.09