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Immunology and Blood Transfusion : Proceedings of the Seventeenth Annual International Symposium on Blood Transfusion, Groningen 1992, Organized by the Red Cross Blook Bank, Groningen-Drenthe :  Proceedings of the Seventeenth Annual International Symposium on Blood Transfusion, Groningen 1992, Organized by the Red Cross Blook Bank, Groningen-Drenthe - C.Th.Smit Sibinga

Immunology and Blood Transfusion : Proceedings of the Seventeenth Annual International Symposium on Blood Transfusion, Groningen 1992, Organized by the Red Cross Blook Bank, Groningen-Drenthe

Proceedings of the Seventeenth Annual International Symposium on Blood Transfusion, Groningen 1992, Organized by the Red Cross Blook Bank, Groningen-Drenthe

By: C.Th.Smit Sibinga (Editor), P. C. Das (Editor), T. H. The (Editor)

Hardcover

Published: December 2009
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In transfusion medicine the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer, where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer. MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibody could play an important role in platelet theory. However, the potential infection risks in transfusion like HIV and HCV remain, but application of molecular biological methods like PCR or RT/PCR has great potentials in detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concentrates, like factor IX and protein C, could reduce patients' immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell mediated immune deficiency, as in ADA.

Moderators and Speakers
Foreword
Cytokines and Cell Mediated Immunologyp. 3
Transfusion-induced Immune Tolerancep. 11
Potential Involvement of Free Radical Reactions in Inactivating Antigen Presenting Cells by Ultraviolet-B Irradiationp. 21
Alloimmunization and Platelet Transfusion Refractorinessp. 37
Graft-versus-host Diseasep. 45
Anti-idiotypic Regulation of the Alloimmune Response in Patients Transfused with Platelet Concentratesp. 57
Options for Prevention of T Cell Alloactivation by Blood Transfusionsp. 77
Use of Monoclonal Antibodies for Immune Purging in Bone Marrow Transplantationp. 85
Reduction of the Immunogenic Capacity of Blood Components for the Prevention of Alloimmunization to White Cellsp. 99
The Effect of Platelets in Red Cell Concentrates on the Leukocyte Depletion Capacity of Leukocyte Depletion Filtersp. 109
Leukocyte Depletion of Red Cell Preparations: Fourth Filter Generation Leads to 4log Reduction. How Far Can/Should We Go?p. 121
Immune Targeting of T-lymphocytesp. 129
Humoral Functions of Immunoglobulin: Relationship to Purification Technology of Intravenous Immunoglobulinp. 137
Immune Adsorption Chromatography for Protein Purificationp. 151
Immunological Principles in Routine Quality Control Immunocharacteristics and Function Testsp. 173
The Emerging Role of MHC Molecules as Signal Transducing Receptorsp. 187
Flow Cytometry in Transfusion Medicinep. 195
New Applications of Molecular Diagnostics in Laboratory Test Systemsp. 219
Prospects and Limitations of Adoptive Immunotherapy and Gene Therapyp. 239
Clinical Strategies for the Prevention of Platelet Alloimmunizationp. 245
Immune Mediated Transfusion Reactions: Bystander Immune Cytolysis - A Frequently Overlooked Mechanism of Hemolysis?p. 255
Blood Transfusion and Cancer: Modulation or Tolerance?p. 261
Blood Product Induced Immunomodulation and Its Clinical Consequencesp. 275
Transfusion Medicine and Immunological Research: Perspective for the Futurep. 285
Indexp. 297
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792323808
ISBN-10: 0792323807
Series: DEVELOPMENTS IN HEMATOLOGY AND IMMUNOLOGY
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 303
Published: December 2009
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 24.77 x 17.15  x 1.91
Weight (kg): 0.7