The objective underlying this book is educational, aiming to advance the development of immunogenetics/histocompatibility and to encourage the international collaboration that is so necessary for the international transplant programme and for research into the genetic predisposition to develop diseases associated with genes in the HLA complex.
The revolution in high-tech molecular biological genome technology has given rise to a prodigious development of molecular techniques for the polymorphism analysis of HLA and the subsequent application of research results in clinical practice. Many new alleles have been discovered and different mechanisms have been shown to generate these new alleles. This has improved both diagnostic efficiency and increased the success of transplantation.
Topics covered include HLA associated susceptibility to autoimmune disease. Strategies and efficiency of BMDW and benefit of collaboration. Optimum selection of unrelated bone marrow donor and extension of the pool of suitable donors by determination of possible mismatches. Identification of sibling pairs using microsatellites across the HLA region. HLA in kidney transplantation. Eurotransplant facts and figures. HLA typing from serology to molecular biology. Evolution of DNA based typing in HLA laboratories. HLA and paternity testing.
|Accreditation with European and American Histocompatibility Immunogenetics Organizations|
|HLA Diversity and Applications|
|HLA and Diseases|
|Bone Marrow Transplantation|
|Transplantation, HLA and non- HLA Aspects|
|Solid Organ and Eye Cornea Transplantation|
|Table of Contents provided by Publisher. All Rights Reserved.|
Series: Nato Science Partnership Subseries: 3
Number Of Pages: 265
Published: 31st May 1997
Country of Publication: NL
Dimensions (cm): 24.4 x 17.0 x 1.7
Weight (kg): 1.31