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Immunobiology of Organ Transplantation - David S. Wilkes

Immunobiology of Organ Transplantation

By: David S. Wilkes (Editor), William J. Burlingham (Editor)

Hardcover Published: 24th June 2004
ISBN: 9780306483288
Number Of Pages: 648

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Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels.
The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.

Introduction and overview
Overview of immunity in transplantation
Immunity of allograft rejection : an overview
MHC : structure and function
HLA immunogenetics and transplantation
Extracellular processing of MHC class I antigens
Genetics of CD1 molecules
Minor histocompatibility antigens : molecular barriers for successful tissue transplantation
Mechanisms of allorecognition
Complement system in allorecognition and rejection of organ transplants
Conceptual models in immunity/tolerance : application to transplantation
Antigen-presenting cells
Dendritic cells in transplantation : origin, immune activation, and allograft tolerance
Monocytes and macrophages in transplantation
Role of B lymphocytes and alloantibodies in organ transplantation
T cells, natural killer cells, NK-T cells
Overview of T-cell phenotype and function
Costimulatory molecules in T-cell activation and transplantation
Regulatory T cells : professional suppressor cells
Cytotoxic T lymphocytes : mechanism of action and role in allograft rejection
Natural killer cells in transplantation : friends or foes?
Nautral killer T(NKT) cells in transplantation
Immunologic tolerance as taught by allografts
The immunobiology of post-transplant lymphoproliferative disorders (PTLD)
Cytokines and chemokines in transplantation
Overview of cytokine structure and function
Chemokines and transplantation
Interaction of innate and acquired immune response : toll receptors - potential link of infection to rejection
Nitric oxide, oxygen radicals
The role of neutrophils in transplantation
Heme oxygenase-1 and transplantation
The heat shock response and transplantation immunology
The role of ischemia reperfusion injury in graft rejection
Matrix proteins, endothelium, epithelium
Extracellular matrix and organ transplantation
Endothelial cell biology : inflammatory biomarkers and risk of transplant atherosclerosis
Epithelial cell biology in organ transplantation
T cell-epithelial cell interactions in organ allograft rejection
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306483288
ISBN-10: 0306483289
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 648
Published: 24th June 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.5 x 17.58  x 4.6
Weight (kg): 1.53

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