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Imaging Drug Action in the Brain - Edythe D. London

Imaging Drug Action in the Brain

Hardcover Published: 1st January 1993
ISBN: 9780849388439
Number Of Pages: 420

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Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail.
Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

Neurobiological Substrates Mediating the Reinforcing Effects of Psychomotor Stimulant and Opiate Drugsp. 1
Receptor Autoradiography as an Aid in Explaining Drug Actionp. 49
In Vitro Autoradiographic Studies of Drugs Acting at Dopamine Receptor Sitesp. 61
Studies of Benzodiazepine Receptors Using In Vivo Autoradiographyp. 81
CNS Receptors for Opioidsp. 119
Imaging Neuroreceptors to Study Drug Action in Living Human Brainp. 177
Metabolic Mapping with Deoxyglucose Autoradiography as an Approach for Assessing Drug Action in the Central Nervous Systemp. 207
Metabolic Mapping of the Effects of Psychomotor Stimulantsp. 247
Positron Emission Tomographic Studies on the Acute Effects of Psychoactive Drugs on Brain Metabolism and Moodp. 265
Use of PET to Study Addiction in Humansp. 281
Inter-Rater Reliability in Positron Emission Tomography Image Analysisp. 297
Immunohistochemistry as a Strategy for Investigating the Functional Neuroanatomy of Drug Actions in the Brainp. 317
In Situ Hybridization Histochemistryp. 337
Identifying and Localizing Gene Expression Important for the Actions of Abused Drugsp. 379
Advanced Electrophysiological Imaging Techniques for Studying Drug Effectsp. 389
Indexp. 405
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780849388439
ISBN-10: 0849388430
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 420
Published: 1st January 1993
Publisher: CRC PR INC
Country of Publication: US
Dimensions (cm): 23.88 x 16.26  x 2.54
Weight (kg): 0.79
Edition Number: 1