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IGFs in the Nervous System (Insulin-Like Growth Factors in the Nervous System : Proceedings - Eugenio E. Muller

IGFs in the Nervous System (Insulin-Like Growth Factors in the Nervous System : Proceedings

By: Eugenio E. Muller (Editor)

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In the last few years, considerable attention has been paid to the presence of insulin-like growth factors (IGFs) and their binding proteins (IGF-BPs) in the brain and peripheral neuronal tissue. IGFs are synthesized within the CNS, are bound to specific IGF-BPs and act on specific receptors. They represent a new class of growth factors and messengers in the brain and the periphery. Written by a group of outstanding experts in the field, the book provides an invaluable forum where important aspects of the production, regulation, biological actions, pathophysiological involvement, therapeutic applications for IGFs in many neurologic and neuromuscular disorders are addressed and critically evaluated.

New Experimental Models for the Study of IGF and IGF-Binding Protein Action in the Brainp. 1
The Insulin-like Growth Factor-I Receptor and the Central Nervous System: Mechanisms Involved in the Prevention of Apoptosisp. 17
IGF-I in Neuronal Differentiation and Neuroprotectionp. 28
Insulin-like Growth Factor I: Regulation and Interactions During Aging-Induced Cognitive Decline and Impairment Within the Hippocampusp. 47
The Role of IGF-I in Cerebellar Granule Cell Survival and Terminal Differentiationp. 60
Regulation of Oligodendrocyte Development and CNS Myelination by IGF-I: Prospects for Disease Therapyp. 72
IGF-I and Glycosaminoglycans Improve Peripheral Nerve Regeneration and Motor Neuron Survival in Models of Motor Neuron Diseasep. 84
The Potential of IGF-I as a Neuronal Rescue Agentp. 96
Neurobiology of rhIGF-I: Rationale for Use in Motor Neuron Diseasep. 105
rhIGF-I for the Treatment of Neuromuscular Disordersp. 115
Insulin-like Growth Factor-I Effects on ADP-Ribosylation Processes and Interactions with Glucocorticoids during Maturation and Differentiation of Astroglial Cells in Primary Culturep. 127
Anti Insulin-like Growth Factor I Antibodies Affect Locomotion and Passive Avoidance Performances in Sprague-Dawley Ratsp. 135
Neuroprotective Effect of GPE Pretreatment on Rat Hippocampal Organotypic Cultures Exposed to NMDAp. 145
Expression of IGF-I and IGF-I Receptor mRNA in Sural Nerves of Diabetic Patientsp. 151
Subject Indexp. 157
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540750420
ISBN-10: 3540750428
Audience: General
Format: Paperback
Language: English
Number Of Pages: 159
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6  x 0.94
Weight (kg): 0.25