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Hypoxia : From Genes to the Bedside - Robert C. Roach


From Genes to the Bedside

By: Robert C. Roach (Editor), Peter D. Wagner (Editor), Peter H. Hackett (Editor)

Hardcover Published: 31st January 2002
ISBN: 9780306466960
Number Of Pages: 445

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Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia.

Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.

Tribute to John T. Reeves
John T. Reeves, MDp. 1
From Genes to the Bedside
Genetic lessons from high altitudep. 7
Genes, environment, and exercisep. 13
Skeletal muscle angiogenesisp. 21
Leukocyte-endothelial interactions in environmental hypoxiap. 39
Training at Altitude for Sea Level Performance
Hypoxia training for sea-level performancep. 61
The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercisep. 75
High Altitude Pulmonary Edema
Update: High altitude pulmonary edemap. 89
Comparative Biology
Phylogenetic comparison and artificial selectionp. 107
Genetic and environmental adaptation in high altitude nativesp. 133
Common themes of adaptation to hypoxiap. 153
Biology of erythropoietinp. 169
Lessons to better understanding of hypoxia sensingp. 189
Erythropoietin use and abusep. 207
Mountain Medicine
Mountaineering in thin airp. 225
Weight loss at high altitudep. 237
Stress Proteins and hypoxia
The heme oxygenase system and cellular defense mechanismsp. 249
Hypoxia-inducible factor in brainp. 273
Transepithelial Sodium Transport
Proton-gated cation channels - neuronal acid sensors in the central and peripheral nervous systemp. 293
Structure function relationships of ENaC and its role in sodium handlingp. 305
Transepithelial sodium and water transport in the lungp. 315
Advances in Cardiorespiratory Control in Hypoxia
Is ventilatory acclimatization to hypoxia a phenomenon that arises through mechanisms that have an intrinsic role in the regulation of ventilation at sea level?p. 339
Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxiap. 349
The pVHL-HIF-1 systemp. 365
Frontiers in Hypoxia Research
Interval hypoxic trainingp. 377
Gene transfer and metabolic modulators as new therapies for pulmonary hypertensionp. 401
Chronic mountain sicknessp. 419
International Working Group for Chronic Mountain Sicknessp. 439
Late and Amended Abstractsp. 441
Indexp. 443
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306466960
ISBN-10: 0306466961
Series: Advances in Experimental Medicine and Biology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 445
Published: 31st January 2002
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.78  x 2.54
Weight (kg): 1.02