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Human Protein Metabolism - Stephen Welle

Human Protein Metabolism

Hardcover

Published: 30th July 1999
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Human Protein Metabolism is a succinct review of hundreds of studies on the regulation of protein mass and protein turnover in the human body. The biochemistry of protein synthesis and breakdown is summarized, and the methods that are used to examine protein metabolism in humans are explained, and their limitations discussed. The book includes chapters that review the effects of nutrition, hormones, metabolic substrates, and physical activity. Various topics of clinical interest are covered, including cancer, diabetes, tissue injury, pregnancy, renal disease, muscular dystrophies, and other conditions. Normal values are presented for turnover of proteins in the whole body and individual organs, and for turnover of many individual proteins. This book will be a valuable resource for physiologists, nutritionists, and clinicians interested in the regulation of body protein stores in health and disease. For scientists primarily interested in the basic aspects of protein metabolism, it shows how the basic knowledge is being applied to the study of humans.

Prefacep. vii
The Importance of Protein Dynamicsp. 1
Protein Structure and the Concept of Protein Turnoverp. 1
Rapid Turnover of Proteins Facilitates Rapid Changes in Protein Concentrationsp. 4
Protein Turnover Is Necessary to Maintain Protein Qualityp. 8
Appendixp. 9
Basic Mechanisms of Protein Turnoverp. 11
Protein Degradationp. 11
Disposal of Amino Acids Generated by Proteolysisp. 17
Protein Synthesisp. 18
Posttranslational Modificationsp. 25
Mitochondrial Protein Synthesisp. 27
Potential Sites of Regulation of Protein Turnoverp. 27
Methods for Studying Protein Metabolism in Humansp. 29
Measuring Changes in Protein Mass of the Bodyp. 29
Whole-Body Protein Turnoverp. 30
Whole-Body Protein Oxidationp. 48
Protein Metabolism in Specific Organs or Limbsp. 50
Incorporation of Tracer into Tissue Proteins or Specific Proteinsp. 56
Polyribosome Abundance as a Measure of Protein Synthesisp. 67
3-Methylhistidine Excretion as a Measure of Myofibrillar Proteolysisp. 68
Markers of Collagen Metabolismp. 69
Radioiodinated Protein Administration to Measure Protein Half-Lifep. 70
Analytical Methodsp. 70
Normative Data from Infancy to Old Agep. 72
Whole-Body N Balancep. 72
Protein Oxidationp. 73
Whole-Body Protein Turnoverp. 74
Protein Turnover in Organs and Tissuesp. 76
Turnover of Specific Proteinsp. 85
Nutritional Influencesp. 91
Acute Responses to Mealsp. 91
Starvationp. 101
Very-Low-Energy Dietsp. 103
Malnutritionp. 105
High Energy Intakep. 115
High Protein Intakep. 118
Summary of Effects of Energy and Protein on Whole-Body Protein Metabolismp. 121
Endocrine, Paracrine, and Autocrine Regulationp. 124
Insulinp. 125
Growth Hormonep. 138
Insulin-Like Growth Factor-I (IGF-1)p. 143
Other Growth Factorsp. 146
Androgensp. 147
Ovarian Steroidsp. 149
Epinephrinep. 151
Cortisolp. 152
Thyroid Hormonesp. 154
Glucagonp. 157
Cytokinesp. 158
Prostaglandinsp. 160
Regulation by Metabolic Substratesp. 161
Amino Acidsp. 161
Glucose and Its Metabolitesp. 172
Triglycerides, Fatty Acids, and Ketone Bodiesp. 173
Summaryp. 176
Physical Activityp. 177
Effect of Inactivity on Protein Metabolismp. 178
Effect of Increased Physical Activity on Protein Metabolismp. 181
Topics of Clinical Interestp. 196
Acidosisp. 196
Alcoholismp. 197
Arthritisp. 198
Cancerp. 199
Cirrhosisp. 204
Diabetesp. 207
Glucocorticoid Therapyp. 208
Heart Diseasep. 210
HIV Infection and AIDSp. 211
Infectionp. 212
Muscular Dystrophiesp. 214
Obesityp. 217
Parenteral and Enteral Nutritionp. 218
Pregnancy and Lactationp. 219
Renal Failurep. 222
Tissue Injury (Trauma, Surgery, Burns)p. 224
Referencesp. 228
Indexp. 283
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780387987507
ISBN-10: 0387987509
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 288
Published: 30th July 1999
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 24.77 x 16.51  x 1.27
Weight (kg): 0.52