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Human Identification : The Use of DNA Markers :  The Use of DNA Markers - B.S. Weir

Human Identification : The Use of DNA Markers

The Use of DNA Markers

By: B.S. Weir (Editor)

Hardcover Published: September 1995
ISBN: 9780792335207
Number Of Pages: 215

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The ongoing debate on the use of DNA profiles to identify perpetrators in criminal investigations or fathers in paternity disputes has too often been conducted with no regard to sound statistical, genetic or legal reasoning. The contributors to Human Identification: The Use of DNA Markers all have considerable experience in forensic science, statistical genetics or jurimetrics, and many of them have had to explain the scientific issues involved in using DNA profiles to judges and juries. Although the authors hold differing views on some of the issues, they have all produced accounts which pay due attention to the, sometimes troubling, issues of independence of components of the profiles and of population substructures. The book presents the considerable evolution of ideas that has occurred since the 1992 Report of the National Research Council of the U.S. Audience: Indispensable to forensic scientists, laying out the concepts to all those with an interest in the use of genetic information. The chapters and exhaustive bibliography are vital information for all lawyers who must prosecute or defend DNA cases, and to judges trying such cases.

Introductionp. 1
A method for quantifying differentiation between populations at multi-allelic loci and its implications for investigating identity and paternityp. 3
The effect of relatedness on likelihood ratios and the use of conservative estimatesp. 13
The effects of inbreeding on DNA profile frequency estimates using PCR-based locip. 21
Correlation of DNA fragment sizes within loci in the presence of non-detectable allelesp. 27
Inference of population subdivision from the VNTR distributions of New Zealandersp. 37
Conditioning on the number of bands in interpreting matches of multilocus DNA profilesp. 51
Match probability calculations for multi-locus DNA profilesp. 55
Population genetics of short tandem repeat (STR) locip. 69
Assessing probability of paternity and the product rule in DNA systemsp. 89
The forensic debut of the NRC's DNA report: population structure, ceiling frequencies and the need for numbersp. 99
Applications of the Dirichlet distribution to forensic match probabilitiesp. 107
The honest scientist's guide to DNA evidencep. 119
A comparison of tests for independence in the FBI RFLP data basesp. 125
Alternative approaches to population structurep. 139
DNA evidence: wrong answers or wrong questions?p. 145
Subjective interpretation, laboratory error and the value of forensic DNA evidence: three case studiesp. 153
Exact tests for association between alleles at arbitrary numbers of locip. 169
A bibliography for the use of DNA in human identificationp. 179
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792335207
ISBN-10: 0792335201
Series: Contemporary Issues in Genetics and Evolution
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 215
Published: September 1995
Publisher: SPRINGER VERLAG GMBH
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 1.42
Weight (kg): 0.49

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