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Human Experimentation : Methodologic Issues Fundamental to Clinical Trials - Ton J. Cleophas

Human Experimentation

Methodologic Issues Fundamental to Clinical Trials

Paperback

Published: 31st July 1999
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Despite their effectiveness in the evaluation of new pharmacological compounds, controlled clinical trials are sometimes inadequate. Using data from the literature as well as from the author's own experience with clinical trials, Human Experimentation: Methodologic Issues Fundamental to Clinical Trials addresses such inadequacies and tries to provide solutions. This work is the first to thoroughly examine these unsolved inadequacies and problems with the design and the execution of clinical trials and, more importantly, to provide solutions for these problems. It is important for anyone who is involved in clinical research: clinicians, pharmacists, biochemists, statisticians, nurses, sponsors, etc., and anyone who is involved in applying results of research to patients, i.e. physicians.

Foreword
Preface
Placebosp. 1
Fundamental Issues of Choosing the Right Type of Trialp. 7
Lack of Real Science of Symptom-Based Carep. 15
Carryover Effects in Clinical Researchp. 25
Criticism of Negative Studies Due to Negative Correlationsp. 37
Between-Group Disparities in Drug Responsep. 48
Specific Problems with Trials of Chronic Diseasesp. 57
Clinical Trials with New Endpointsp. 66
Linear Scale Assessment of Relevant Domains of Quality of Life - an examplep. 73
Item Response Modeling and Quality of Lifep. 81
Is Selective Reporting of Well-Designed Research Unethical as Well as Unscientific?p. 90
Informed Consent Under Scrutiny, Suggestions for Improvementp. 99
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792358275
ISBN-10: 0792358279
Audience: General
Format: Paperback
Language: English
Number Of Pages: 120
Published: 31st July 1999
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 0.64
Weight (kg): 0.18