Human Cerebrospinal Fluid and Cerebrovascular Barrier

By: Hiroshi Ishikawa (Editor), Horst Schroten (Editor), Christian Schwerk (Editor)

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eText | 11 April 2025

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This book offers a basic understanding of the complex mechanisms that protect the brain from harmful substances while still allowing for essential functions such as nutrient transport and waste removal. It explores the blood-cerebrospinal fluid barrier (BCSFB) and the blood-brain barrier (BBB) in depth, focusing on the latest research, innovative techniques, and unique perspectives from researchers worldwide. The book also examines the clinical relevance of brain barrier dysfunction, with a particular focus on multiple sclerosis (MS) and the potential role of brain barriers in the development of MS, intricate relationship between brain barriers and infectious diseases and much more. With contributions from experts in neurobiology, microbiology, and biophysics, this book provides a multidisciplinary perspective.

Extensive research has been conducted on the cerebrovascular or cerebrospinal fluid barrier function. The recent development of a functional epithelial cell line derived from a human choroid plexus papilloma has paved the way for an in vitro model of the choroid plexus, which has been instrumental in elucidating the interplay between infection, metabolism, physiological functions, and disease. This book is an effort by the Editors to raise public knowledge of the cerebrovascular and cerebrospinal fluid barriers.

With broad coverage of topics in "Human Cerebrospinal Fluid and Cerebrovascular Barrier", it is ideal for researchers studying cerebrovascular or cerebrospinal fluid barrier interested in staying up to date on the latest developments. Healthcare providers and researchers working to develop new treatments for MS, infectious diseases of the central nervous system and other neurological disorders will also value this book. The book provides students of medicine, pharmacy, biology, and engineering with a comprehensive understanding of the structure and function of brain barriers. Those seeking a thorough introduction to the field will also find the book enjoyable.