Hormone Signaling

By: Vincent Goffin, Paul A. Kelly

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Hardcover | 31 March 2002

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334 Pages

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24.77 x 16.51 x 1.91

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Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis.
The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.

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Contents
List of Contributors
Signaling Websites
Preface
Acknowledgements
Fundamental Mechanisms in Signaling	p. 1
Protein Phosphorylation and Protein-Protein Interactions	p. 3
Control of Signaling by Tyrosine Phosphatases	p. 21
Spatio-Temporal Parameters: The Case of the MAP Kinase Pathway	p. 37
Receptor Tyrosine Kinases	p. 55
The EGF Receptor Signaling System. A Model for Growth Factor Receptor Signaling	p. 57
Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways: Similarities and Differences	p. 81
Cytokine Receptors	p. 101
The JAK-STAT Pathway	p. 103
Prolactin and Growth Hormone Receptors. Signal Transduction and Crosstalk	p. 121
Erythropoietin, Thrombopoietin and Leptin Receptors	p. 145
G Protein-Coupled Receptors	p. 179
G Proteins and G Protein-Coupled Receptors: Overview	p. 181
Gonadotropin and TSH Receptors	p. 199
Endothelin G Protein-Coupled Receptors	p. 221
Nuclear Receptors	p. 239
Signal Transduction and Structure of Nuclear Receptors	p. 241
Estrogen Receptor Beta: How Awareness of ER[beta] Affects Our Understanding of Estrogen Action	p. 269
Sensors for Metabolic Control. A Regulatory Network of Nuclear Receptors	p. 283
Table of Contents provided by Blackwell. All Rights Reserved.

Hormone Signaling

At a Glance

Hardcover

Shipping

How to return your order

Defective items

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