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Hepatobiliary Cancer : Cancer Treatment and Research - Paul H. Sugarbaker

Hepatobiliary Cancer

Cancer Treatment and Research

By: Paul H. Sugarbaker (Editor)

Hardcover Published: 31st May 1994
ISBN: 9780792325017
Number Of Pages: 326

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When one deals with cancer, the hepatobiliary malignancies present a challenge to the oncologist that can be best characterized as a series of unsolved clinical and biological dilemmas. Liver metastases from colorectal and other gastrointestinal malignancies, hepatocellular carcinoma, cholangiocarcinoma and gall bladder cancer present an array of problems but have two features in common; these are high morbidity and mortality with an overall poor result from treatment.
Even though there are many reasons to be discouraged in the treatment of hepatobiliary cancer, there are some unique features that the liver presents which allow innovative treatment options. First, the liver is one of the few organs in the body that will regenerate over time. Patients who can be made disease free will usually return to a fully functional state despite the ablation of up to 80% of this organ. Secondly, the liver has an isolated vasculature. Intraarterial infusion, portal venous infusion, and even isolated perfusion are not only possible but have been accomplished and been used in clinical trials. Third, this organ is extremely well characterized radiologically and the progress of treatments can be monitored with great accuracy. Tumor markers assist in this follow-up. Finally, this is an organ that can be transplanted with great success when there is benign disease. If one could control small volume systemic malignancy outside of the liver, transplantation would offer a curative approach in a large majority of patients.
The book presents both the credits and debits that one must encounter in dealing with hepatobiliary cancer. The traditional discouragement is blended with opportunity so that the oncologist finds himself wishing to know more and in knowing more to do more in the treatment of hepatobiliary cancer.

List of Contributors
Preface
Inefficiency of metastasis from colorectal carcinomasp. 1
Cytoreductive approach to treatment of multiple liver metastasesp. 13
Hepatoma registry of the western worldp. 21
Resection of hepatic metastases from colorectal carcinomap. 33
Surgical management of hepatic metastases from large bowel cancerp. 43
Repeat resections of primary hepatic malignanciesp. 53
Repeat resections for recurrent colorectal liver metastasesp. 57
Liver transplantation as an option for primary malignancyp. 63
Surgical treatment of cholangiocarcinomap. 75
Treatment of gallbladder cancerp. 97
Use of clamps in hepatobiliary surgeryp. 111
Chemotherapy after hepatic resection of colorectal metastasesp. 121
Radiological evaluation of metastases to the liver: The Emory experiencep. 129
Hepatic vascular exclusion for hepatic resectionp. 147
Radiologic evaluation and treatment of gallbladder and biliary tree carcinomap. 157
Repeat liver resections from colorectal metastasisp. 185
Intraoperative ultrasound and liver tumorsp. 197
Parenchymal dissection techniquesp. 221
Surgical resection and transplantation for hepatocellular carcinomap. 231
Causes of death in patients undergoing liver surgeryp. 241
Liver transplantation as an option in patients with cholangiocellular and bile duct carcinomap. 259
Surgical management of hepatomap. 277
Liver resectability based on physical characteristicsp. 291
Prediction of the safe limits of hepatectomy by combined volumetric and functional measurements in patients with impaired hepatic functionp. 293
Quantitative liver function testing as a preoperative parameter in hepatic resectionp. 301
Decreasing posthepatectomy liver failurep. 307
Current status in liver function tests: Technical considerationsp. 313
Indexp. 315
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792325017
ISBN-10: 079232501X
Series: Cancer Treatment and Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 326
Published: 31st May 1994
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 1.47