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Hepatitis C Virus : From Laboratory to Clinic - Mark A. Feitelson

Hepatitis C Virus

From Laboratory to Clinic

Paperback

Published: 29th April 2002
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Hepatitis C infects 170 million people worldwide, and has been labelled the 'silent epidemic' as a result of its concealed attack on the liver. This multidisciplinary overview covers basic concepts related to the discovery of the virus, development of serological and nucleic acid tests to detect infection, the structure of the virus genome, generation of virus gene products, and proposed replication scheme. It then goes on to introduce the epidemiology, transmission, pathogenesis of infection, the development of hepatocellular carcinoma associated with chronic virus infection, and current strategies for treatment. The book then discusses advances in cell culture systems, animal models of infection, and emerging treatments and vaccine development. Through its coverage of basic science, clinical consequences, and methods of research, this integrated and accessible account will be of immense value to biomedical scientists and clinicians alike, and a useful introduction for all those studying the virus and its effects.

'The diligent reader of this book will come away with a thorough grounding in the virology and immunopathology of hepatitis C, know what the major sources of further information are, and understand why this infection is at once enigmatic, insidiously progressive, difficult to treat and hard to immunize against. Thoroughly recommended! Epidemiology and Infection

Preface
Basic Principles
Background
The virus
Epidemiology and transmission
Natural history of infection
Pathogenesis of infection
HCV and hepatocellular carcinoma
Extrahepatic sites for hepatatis C
HCV and autoimmune diseases
Clinical aspects of the disease
Current therapeutic approaches
NS5A and interferon resistance
Recent Advances
Propagation of virus in culture
Understanding the natural history of HCV
HCV animal models
Vaccine research
Experimental Approaches
New systems to understand HCV biology
New antiviral screening assays
Antiviral gene therapy
Protocols and Techniques
Sample collection, preparation and storage
HCV RNA in blood and tissue samples
HCV RNA genotypes and quasispecies
Replication of HCV in tissue culture
NS3 protease, helicase and NTPase
Characterization of NS5B
Outstanding Questions and Emerging Areas for Investigation
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521799591
ISBN-10: 0521799597
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 270
Published: 29th April 2002
Publisher: Cambridge University Press
Country of Publication: GB
Dimensions (cm): 24.8 x 17.4  x 1.6
Weight (kg): 0.58