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Hemochromatosis : Genetics, Pathophysiology, Diagnosis and Treatment - James C. Barton

Hemochromatosis

Genetics, Pathophysiology, Diagnosis and Treatment

By: James C. Barton (Editor), Corwin Q. Edwards (Editor)

Hardcover Published: 13th January 2000
ISBN: 9780521593809
Number Of Pages: 616

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Once considered a rare condition, hemochromatosis is now acknowledged as one of the commonest inherited disorders, affecting one in two hundred people of Western Caucasian descent and in the U.S. alone, over one million people. This is the most comprehensive clinical reference yet on hemochromatosis. The international team of 94 authors from twelve countries includes specialists in internal medicine, hematology, hepatology, genetics, biochemistry, and molecular biology. In 57 in-depth chapters they cover all aspects of pathophysiology, epidemiology, diagnosis and treatment. The text thoroughly explains the latest developments in the genetics of the disorder, including sections on screening, diagnostic techniques, and clinical complications. In addition, chapters consider social and ethical issues. With over 200 illustrations--including 40 color plates--this is today's definitive resource for all clinicians involved in the management of hemochromatosis, and for scientists interested in iron metabolism and iron overload.

'This is 'the bible' of hemochromatosis ... This is the best, most comprehensive review of hemochromatosis and iron metabolism that I have ever encountered. It will become a required reference for anyone treating or researching this disease.' Lisa Boggio, MD 'James Barton and Corwin Edwards have assembled a distinguished international array of nearly 100 contributors to cover every aspect of the subject. It is a massive undertaking and is the current definitive text on haemochromatosis. Clearly written and well referenced, there are reviews by researchers - many of whom have been leaders in this topic for over 30 years.' James S. Dooley, The Lancet 'Throughout this book, the reader can feel the excitement sparked by the discovery of the hemochromatosis (HFE) gene ... Specialists will find up-to-date information and invaluable bibliographic resources ... The book contains discussions of important issues related to screening for hemochromatosis and a remarkable chapter on social and ethical issues.' The New England Journal of Medicine 'Clearly written and well referenced, there are reviews by researchers - many of whom have been leaders in this topic for over 30 years ... comprehensive and informative reference text. Hemochromatosis will be valuable not only for scientists and clinicians who are involved in this area, but also for individuals who need a state-of-the-art review of a specific issue.' James S. Dooley, The Lancet Barton and Edwards have assembled experts from around the world to write highly authoritative articles about all aspects of hemochromatosis. Molecular genetics, genetic epidemiology, pathophysiology, clinical management, and screening are the main topics. Ethical and social issues related to hemochromatosis are also considered. Throughout this book, the reader can feel the excitement sparked by the discovery of the hemochromatosis (HFE) gene. This book is particularly strong in its coverage of clinical genetics ... This book, written by 93 diverse authors, is nevertheless a tight collection of compelling and informative chapters, each one contributing to the cogency of the overall discussion.' The New England Journal of Medicine 'Hemochromatosis reflects the current wealth of clinical and experimental progress in the area, and reviews the changing understanding of the disorder, its cause, diagnosis, and management.' James S. Dooley, The Lancet 'This large volume is a remarkable resource of information about haemochromatosis, ranging from the history to social and ethical issues of genetic testing, and including some topics which usually receive little attention, such as the absorption for other metals and infections and immunity.' Mark Worwood, Hum Genet 'Excellent.' Journal of Gastroenterology '... highlights the importance and advances made relative to hemochromatosis and places this disease in perspective not only as an important entity in inherited disease but in all systematic medicine.' G. Falkson, Oncology

Introduction to Hemochromatosis
Genetics of Hemochromatosis
Metal Absorption and Metabolism in Hemochromatosis
Diagnostic Techniques for Iron Overload
Complications of Iron Overload
Therapy of Hemochromatosis and Iron Overload
Infections and Immunity in Hemochromatosis
Hemochromatosis Heterozygotes
Relationship of Hemochromatosis to Other Disorders
Animal Models of Hemochromatosis and Iron Overload
Screening for Hemochromatosis
Hemochromatosis
Final Issues
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521593809
ISBN-10: 0521593808
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 616
Published: 13th January 2000
Publisher: CAMBRIDGE UNIV PR
Country of Publication: GB
Dimensions (cm): 28.19 x 22.35  x 4.32
Weight (kg): 2.45