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Handbook of Platelet Physiology and Pharmacology - Gundu H. R. Rao

Handbook of Platelet Physiology and Pharmacology

By: Gundu H. R. Rao (Editor)

Paperback

Published: 30th June 1999
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This publication reviews blood platelet biochemistry, physiology, pharmacology and function. It provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs. The book presents an overview of biochemistry, receptor biology, signaling mechanisms, calcium homeostasis, molecular pathology, and comparative physiology of platelets, as well as the pharmacology of antiplatelet drugs and clinical trials. It should prove a useful reference for haematologists, cell biologists, biochemists, pathologists, and other researchers in the areas of cell biology, pathobiology, atherosclerosis, thrombosis, and biomedical engineering.

Contributorsp. IX
Prefacep. XII
Introduction
Platelet Physiology and Pharmacology: An overviewp. 1
Receptor Biology
Human Platelet Thrombin Receptors and the two Receptor Model for Platelet Activationp. 21
Platelet Thromboxane Receptors: Biology and Functionp. 38
Collagen Receptors: Biology and Functionsp. 80
Adenosine Receptors: Biology and Functionp. 102
Platelet Activating Factor and Plateletsp. 120
Platelet Glycoprotein 1b-V-1X: Biology and Functionp. 142
Fibrinogen Receptors: Biology and Functionp. 162
Platelet Biochemistry
Biochemistry of Platelet Activationp. 188
GTP Binding Proteins in Plateletsp. 238
Platelet Cyclic Nucleotide Phosphodiesterasesp. 251
Polyenoic Fatty Acids and Platelet Functionp. 268
Phospholipase A[subscript 2] in Plateletsp. 293
Experimental Physiology
Platelet Biorheology: Adhesive Interactions in Flowp. 315
Platelet Vessel Wall Interactionsp. 342
Platelet-Biomaterial Interactionsp. 362
Comparative Physiology of Platelets from Different Speciesp. 379
Platelet Pathology
The Molecular Pathology of Glanzmann's Thrombastheniap. 394
Congenital Disorders of Platelet Signal Transduction and Secretionp. 424
Biochemistry of Altered Platelet Reactivity in Hypertensionp. 439
Platelet Pharmacology
Nitric Oxide-mediated Regulation of Platelet Functionp. 458
Aspirin, Prostaglandins and Platelet Function: Pharmacology and Thrombosis Preventionp. 478
Current Developments in Anticoagulant and Antithrombotic Agentsp. 495
Randomized Trials of Antiplatelet Therapyp. 526
Subject Indexp. 549
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780792385387
ISBN-10: 0792385381
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 553
Published: 30th June 1999
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.6 x 16.2  x 3.6
Weight (kg): 1.05