+612 9045 4394
 
CHECKOUT
Handbook of Pediatric Transfusion Medicine - Naomi Luban

Handbook of Pediatric Transfusion Medicine

Hardcover

Published: 28th January 2004
Ships: 7 to 10 business days
7 to 10 business days
$375.75
or 4 easy payments of $93.94 with Learn more

8 1/2 X 10 15/16 in Blood Donation
Component Preparation and Storage
Blood Components
Red Blood Cell Antigens and
Human Blood Groups
Pretransfusion Compatibility TestingSerologic Investigation of Unexpected Antibodies
Leukoreduced Products: Prevention of Leukocyte-Related Transfusion-Ass ociated Adverse Effects
Preparation of Blood Components to Reduce Cytomegalovirus and Other Infectious Risks
Irradiate d Products
Washed and/or Volume-Reduced Blood Components
Technical Considerations/Mechanical Devices
Red Blood Cell Transfusions in the Neonate, Infant, Child, and Adolescent
Transfusion of the Pediatric Surgery, Trauma, and Intensive C are Unit Patient
Pediatric Transfusion in Developing Countr ies
Exchange Transfusion in the Infant
Granulo cyte Transfusions in the Neonate and Child
Extracorporeal M embrane Oxygenation and Cardiopulmonary Bypass
Hemolytic Di sease of the Newborn
Hemoglobinopathies
The Bl

Prefacep. xiii
Acknowledgmentsp. xv
About the Editorsp. xvii
List of Contributorsp. xix
Blood Donationp. 1
Overviewp. 1
Donor Recruitmentp. 1
Autologous Donationp. 2
Directed Donationp. 3
Limited Donor Exposurep. 3
Blood Collectionp. 3
Apheresisp. 8
Plasmapheresisp. 8
Component Preparation and Storagep. 11
Introductionp. 11
Unique Transfusion Needs of the Neonatal and Pediatric Patientp. 11
Blood Donation Issuesp. 17
Anticoagulant-Preservative Solutionsp. 18
Individual Components for Transfusionp. 19
Record Keeping for Component Preparationp. 22
Storage of Blood and Blood Productsp. 23
Blood Componentsp. 27
Introductionp. 27
Whole Blood and Packed Red Blood Cellsp. 27
Plateletsp. 31
Granulocytesp. 33
Plasma Productsp. 34
Cryoprecipitatep. 36
Orderingp. 36
Coagulation Factorsp. 37
Albuminp. 38
Gamma-Globulinsp. 39
Red Blood Cell Antigens and Human Blood Groupsp. 45
Introductionp. 45
ABO Blood Group Systemp. 45
RH Blood Group Systemp. 47
Kell Blood Group Systemp. 48
Duffy Blood Group Systemp. 49
Clinical Significancep. 49
Kidd Blood Group Systemp. 49
MNS Blood Group Systemp. 50
P Blood Group Systemp. 51
Lutheran Blood Group Systemp. 51
Lewis Blood Group Systemp. 52
Diego Blood Group Systemp. 53
Cartwright Blood Group Systemp. 53
Xg Blood Group Systemp. 53
Scianna Blood Group Systemp. 54
Dombrock Blood Group Systemp. 54
Colton Blood Groupp. 55
LW Blood Group Systemp. 56
Chido-Rogers Blood Group Systemp. 56
Hh Blood Group Systemp. 56
XK Blood Group Systemp. 57
Gerbich Blood Group Systemp. 57
Cromer Blood Group Systemp. 57
Knops Blood Group Systemp. 58
Indian Blood Group Systemp. 58
Ok Blood Group Systemp. 58
RAPH Blood Group Systemp. 58
JMH Blood Group Systemp. 59
Cost Blood Group Collectionp. 59
Er Blood Group Collectionp. 59
Ii Blood Group Collectionp. 59
Globoside Collectionp. 60
Low-Prevalence Antigensp. 60
High-Prevalence Antigensp. 61
Pretransfusion Compatibility Testingp. 63
Introductionp. 63
ABO(H)p. 63
Rh(D)p. 65
Other Red Cell Antigensp. 66
Direct Antiglobulin Testp. 67
Antibody Detection Test (Screen)p. 67
Crossmatch (XM)p. 69
Turnaround Timesp. 70
Serologic Investigation of Unexpected Antibodiesp. 73
Introductionp. 73
Common Antibody Identification Methodsp. 73
Process for Evaluation of Positive Antibody Detection Testsp. 77
Leukoreduced Products: Prevention of Leukocyte-Related Transfusion-Associated Adverse Effectsp. 85
Introductionp. 85
Rationale for Leukoreduction of Blood Componentsp. 85
Specific Indications for LR Productsp. 85
Contraindications, Side Effects, and Hazardsp. 88
Leukoreduction Technologiesp. 88
Products, Standards, and Quality Controlp. 89
Universal Leukoreductionp. 89
Leukoreduced Blood Products and Pediatric Transfusion Medicinep. 90
Preparation of Blood Components to Reduce Cytomegalovirus and Other Infectious Risksp. 93
Introductionp. 93
Red Blood Cell and Platelet Components with Reduced Infectious Risksp. 93
Plasma Components, Derivatives, and Factors to Eliminate Pathogensp. 97
Nucleic Acid Targeted Inactivation Strategiesp. 97
Irradiated Productsp. 101
Historyp. 101
Pathogenesisp. 101
Clinical Manifestationsp. 102
Diagnosis of TA-GVHDp. 102
Time Course of Microchimerismp. 102
Groups at Riskp. 103
The Irradiation Processp. 103
Instrumentation for Irradiationp. 104
Components to be Irradiatedp. 105
Storage of Red Cells and Platelets after Irradiationp. 106
Selection of Radiation Dosep. 107
Quality Assurance Measuresp. 108
Confirming That Irradiation Occurredp. 108
New Methods in the Prevention of TA-GVHDp. 109
Treatment of TA-GVHDp. 110
Washed and/or Volume-Reduced Blood Componentsp. 113
Introductionp. 113
Washed Red Blood Cellsp. 113
Washed And Volume-Reduced Platelet Concentratesp. 117
Technical Considerations/Mechanical Devicesp. 121
Introductionp. 121
Intravenous Delivery Systems for Blood and Componentsp. 121
Exchange Transfusion in the Newbornp. 126
Red Blood Cell Transfusions in the Neonate, Infant, Child, and Adolescentp. 131
Introductionp. 131
RBC Transfusions for Children and Adolescentsp. 131
RBC Transfusions for Neonates and Infantsp. 133
Transfusion of the Pediatric Surgery, Trauma, and Intensive Care Unit Patientp. 137
Abstractp. 137
Age, Size, and Rate of Transfusionp. 137
Red Blood Cell Transfusionp. 139
Platelet Transfusionsp. 140
Cryoprecipitate and Fresh Frozen Plasmap. 142
Hemostatic Agents in Acute Carep. 146
Pediatric Transfusion in Developing Countriesp. 149
Introductionp. 149
Special Transfusion Issues in Resource-Restricted Countriesp. 149
Blood Collection and Processing in Developing Countriesp. 151
Risks of Infectious Disease Transmission by Transfusionp. 153
Current Transfusion Practicesp. 155
Prevention Measures to Reduce Need for Transfusionp. 156
Exchange Transfusion in the Infantp. 159
Introductionp. 159
Rationale and Indicationsp. 159
Procedurep. 161
Selection of Donor Bloodp. 162
Complicationsp. 163
Granulocyte Transfusions in the Neonate and Childp. 167
Abstractp. 167
Introductionp. 167
Myelopoiesisp. 168
Neonatal Neutropenia and Dysfunctionp. 168
Childhood Neutropeniap. 169
Mobilization of Donor Granulocytesp. 171
Therapeutic Granulocyte Transfusions in Children and Adultsp. 173
Granulocyte Transfusion in the Neonatep. 177
Summary and Recommendations of Granulocyte Transfusionsp. 178
Extracorporeal Membrane Oxygenation and Cardiopulmonary Bypassp. 181
Introductionp. 181
Circuit for ECMO and CPBp. 181
ECMOp. 183
CPBp. 186
Hemolytic Disease of the Newbornp. 191
Introductionp. 191
Immune-Mediated Hemolytic Diseasep. 191
Rh Hemolytic Diseasep. 192
ABO Hemolytic Diseasep. 194
Hemolytic Disease Due to Other Red Cell Antibodiesp. 195
T Activationp. 198
Autoimmune Hemolytic Diseasep. 199
Red Cell Enzyme Deficienciesp. 199
Red Cell Membrane Defectsp. 200
Disorders of Hemoglobin Synthesisp. 201
Other Causes of Hemolytic Disease in Neonatesp. 202
Therapyp. 202
Hemoglobinopathiesp. 209
Introductionp. 209
Sickle Cell Diseasep. 209
Thalassemiasp. 217
The Bleeding Child: Congenital and Acquired Disordersp. 221
Abstractp. 221
Introductionp. 221
Coagulation Overviewp. 221
Clinical Evaluation of Bleeding Problemsp. 222
Laboratory Evaluationp. 223
Specific Factor Assaysp. 225
Inherited Coagulation Disordersp. 225
Acquired Hemorrhagic Disordersp. 238
Transfusion of the Patient with Autoimmune Hemolysisp. 245
Introductionp. 245
Clinical Presentation and Laboratory Findingsp. 245
Classificationp. 245
Warm Autoimmune Hemolytic Anemiap. 246
Cold Agglutinin Syndromep. 247
Mixed-Type Autoimmune Hemolytic Anemiap. 248
Drug-Induced Hemolytic Anemiap. 248
Less Common Types of Autoimmune Hemolytic Anemiap. 249
Transfusion Therapy in Autoimmune Hemolytic Anemiap. 250
Platelet Transfusions in the Infant and Childp. 253
Introductionp. 253
Platelet Products and Special Preparationsp. 253
Platelet Transfusions in Childrenp. 255
Platelet Transfusions in Neonatesp. 259
Reactions to Platelet Transfusionsp. 263
Potential Alternatives to Platelet Transfusionsp. 265
Bone Marrow-Derived Stem Cellsp. 271
Introductionp. 271
Product Descriptionp. 271
Collection and Storagep. 273
Special Preparation and Processingp. 274
Expected Responsep. 278
Alternative HPC Sourcesp. 279
Peripheral Blood Stem Cellsp. 283
Introductionp. 283
Product Descriptionp. 283
Collectionp. 285
Special Preparationp. 287
Ordering and Administrationp. 290
Potential Adverse Effectsp. 291
Alternative HPC Sourcesp. 292
Umbilical Cord Blood Stem Cellsp. 295
Introductionp. 295
Collection, Storage, and Handlingp. 295
Clinical Applicationsp. 297
Transfusion Reactionsp. 301
Introductionp. 301
Acute Hemolytic Transfusion Reactionsp. 301
Febrile Nonhemolytic Transfusion Reactionsp. 307
Allergic Transfusion Reactionsp. 309
Delayed Hemolytic Transfusion Reactionsp. 311
Special Considerations for Newborn Infantsp. 314
Noninfectious Complications of Pediatric Transfusionp. 317
Introductionp. 317
Transfusion Reactionsp. 317
Metabolic Complicationsp. 320
Cardiac Overloadp. 322
Alloimmunizationp. 322
T Antigen Activationp. 322
Dilutional Coagulopathyp. 323
Complications of Iron Overload from Chronic Transfusionp. 323
Infectious Complicationsp. 329
Introductionp. 329
Human Immunodeficiency Virusp. 329
Hepatitisp. 331
Human T-Cell Lymphotropic Virus (HTLV)p. 333
Cytomegalovirusp. 334
Parvovirus B19p. 335
Parasitic Infectionsp. 336
Creutzfeldt-Jakob Diseasep. 337
Bacterial Infectionsp. 337
Therapeutic Apheresisp. 343
Introductionp. 343
Goals of Therapeutic Apheresisp. 343
Indication Categoriesp. 345
Physiology and Adverse Effectsp. 346
General Approach to Pediatric Patients Needing Therapeutic Apheresisp. 347
Planning Pediatric Proceduresp. 348
Vascular Accessp. 348
Hemodynamic Challengesp. 349
Procedural Modifications for Pediatric Patientsp. 349
Therapeutic Cytapheresisp. 353
Introductionp. 353
Evidence-Based Practice Guidelinesp. 353
General Technical Considerations for Pediatricsp. 354
Erythrocytapheresis/Red Cell Exchange Transfusionp. 354
Leukapheresisp. 359
Plateletpheresis (Thrombocytapheresis)p. 361
Adverse Reactionsp. 362
Therapeutic Plasma Exchange: Rationales and Indicationsp. 365
Introductionp. 365
Guillain-Barre Syndromep. 365
Chronic Inflammatory Demyelinating Polyneuropathyp. 367
Sydenham's Chorea and PANDASp. 367
Rasmussen's Encephalitisp. 368
Thrombotic Thrombocytopenic Purpurap. 369
Hemolytic Uremic Syndromep. 370
Familial Hypercholesterolemiap. 370
Refsum's Diseasep. 371
Focal Segmental Glomerulosclerosisp. 371
Solid Organ Transplantationp. 372
Other Diseasesp. 373
Transfusion Formulasp. 375
Approximate Blood Volumes (BV)p. 375
Plasma Volume (PV)p. 375
Red Blood Cell (RBC) Transfusionp. 375
Estimation of Blood Volume Exchangedp. 375
Partial Exchange Transfusion for Polycythemiap. 376
Exchange Transfusion for Anemiap. 376
Preparation of Blood Product with Specific Hct Using FFPp. 376
Platelet Transfusionp. 376
Coagulationp. 376
Massive Transfusionsp. 377
Composition of Anticoagulantsp. 377
Indexp. 379
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780123487766
ISBN-10: 0123487765
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 394
Published: 28th January 2004
Publisher: ACADEMIC PR INC
Country of Publication: US
Dimensions (cm): 28.45 x 22.35  x 2.79
Weight (kg): 1.23