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Handbook of Clinical Neurology - Vol 79 (1), The Human Hypothalamus Basic and Clinical Aspects : Basic and Clinical Aspects, Part I: Volume 79 - Aminoff

Handbook of Clinical Neurology - Vol 79 (1), The Human Hypothalamus Basic and Clinical Aspects

Basic and Clinical Aspects, Part I: Volume 79

By: Aminoff

Hardcover Published: 15th December 2003
ISBN: 9780444513571
Number Of Pages: 508

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This volume in the Handbook of Clinical Neurology (Series Editors: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; Fran‡ois Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) is the first major account of the human hypothalamus. The human hypothalamus is an extremely complex structure and consists of a large number of very different functional units (nuclei) that are not included in the standard neuropathological investigation of the human brain. In fact, on the basis of their chemical nature, many of these functional systems have only recently been distinguished through modern neurobiological techniques. Since the finding that the hypothalamus contributes to memory and attention deficits in the dementias, that a disorder of the orexin/hypocretin system is the cause of narcolepsy, that hypothalamic hamartomas are responsible for gelastic epilepsy, that the subthalamic structure where depth electrodes are placed in parkinsonian patients is a hypothalamic structure, and that the source of cluster headache is situated in the hypothalamus, this perception of the hypothalamus as a neuroendocrine structure, of limited interest to neurologists and psychiatrists, is rapidly changing. Moreover, the hypothalamus now appears to be the basis of many signs and symptoms of disorders situated on the border between neurology and psychiatry, such as depression, eating disorders, aggression, and mental retardation. As a consequence, the hypothalamus has become a meeting point for neuroscientists, neurologists and psychiatrists, endocrinologists, and pediatricians, and as such is an important starting point for the new (third) series of the Handbook of Clinical Neurology.

'To many neuropathologists, the human hypothalamus may be nothing more than a few ml of neuroendocrine tissue that is all too often ignored or excluded from standard neuropathological examinations or brain maps. With the advent of the first two volumes of the third series of the "Handbook of Clinical neurology", Dick Swaab changes that perception permanently by compiling and reviewing simply everything there is to know about this structure in a 1,000-page monograph............If one book can change the traditional clinical perception of the hypothalamus as an evolutionary ancient, endocrine structure of little importance, this monograph will.' - Journal of Neuropathology and Experimental Neurology

'It is unusally rich in historical detail, and the illustrations are of exeptionally good quality' - Journal of Neuroendocrinology

Nuclei of the human hypothalamus: cytoarchitecture, chemoarchitecture, functional neuroanatomy, topographic neuropathology
Introduction
Anatomical borders of the hypothalamus
Strategic research and structure-function relationships
The autopsy and brain banking
Confounding factors
Parameters of neuronal metabolic activity in postmortem tissue
Fetal hypothalamic development and adult markers of the human hypothalamic nuclei
Nucleus basalis of Meynert (NBM) and diagonal band of Broca (DBB)
Anatomy
Chemoarchitecture
Alzheimer's disease
Neuronal loss vs. atrophy
Neurotrophin receptors in the NBM
Other disorders affecting the NBM and DBB
Islands of Calleja, insulae terminalis
Suprachiasmatic nucleus (SCN) and pineal gland
Circadian, seasonal, monthly and circaseptan rhythms in the SCN
SCN development, birth and circadian rhythms
Circadian and circannual rhythms in aging and Alzheimer's disease
The SCN in relation to sex, reproduction and sexual orientation
Melatonin and its receptors
Sexually dimorphic nucleus of the preoptic area (SDN-POA) = intermediate nucleus = interstitial nucleus of the anterior hypothalamus (INAH-1) = preoptic nucleus
Nomenclature and homology to the rat SDN-POA
Development, sexual differentiation, aging and Alzheimer's disease
Other sexual dimorphisms
Interstitial nucleus of the anterior hypothalamus (INAH)-2 and -3
Anterior commissure, the interthalamic adhesion, corpora mamillaria and the third ventricle
Sex hormone receptor distribution
Bed nucleus of the stria terminalis (BST) and the septum
The BST
Reversed sex differences in the BST in transsexuals
The septum verum
Supraoptic and paraventricular nucleus (SON, PVN)
The fetal SON, PVN in birth and development
Colocalization of tyrosine-hydroxylase (TH) with oxytocin and vasopressin
The SON and PVN in aging and Alzheimer's disease
(a) Vasopressin secretion in various disorders: (b) Vasopressin administration in various disorders
Corticotropin-releasing hormone (CRH) neurons in the PVN
Thyrotropin-releasing hormone (TRH) neurons in the PVN
Other neuroactive compounds in the SON, PVN and periventricular nucleus
Ventromedial nucleus (VMN; nucleus of Cajal)
Dorsomedial nucleus (DMN)
Infundibular nucleus (arcuate nucleus), subventricular nucleus and median eminence
Lateral tuberal nucleus (NTL)
Chemoarchitecture and function
The NTL in neurodegenerative diseases
Tuberomamillary complex
Anatomy
Neurodegenerative diseases and schizophrenia
Posterior hypothalamic area
Lateral hypothalamic area (LHA) and intermediate hypothalamic area (IHA)
Subthalamic nucleus and zona incerta
Subthalamic nucleus
Zona incerta
Corpora mamillaria
References
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780444513571
ISBN-10: 0444513574
Series: Handbook of Clinical Neurology : Book 79
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 508
Published: 15th December 2003
Publisher: Elsevier Science & Technology
Country of Publication: GB
Dimensions (cm): 26.04 x 19.68  x 3.18
Weight (kg): 1.7
Edition Number: 3

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