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Handbook of Clinical Neurology, Third Series - Vol 80 Part 2 : Human Hypothalamus: Basic and Clinical Aspects, Part II Basic and Clinical Aspects: Pt. 2 Volume 80 - Swaab

Handbook of Clinical Neurology, Third Series - Vol 80 Part 2

Human Hypothalamus: Basic and Clinical Aspects, Part II Basic and Clinical Aspects: Pt. 2 Volume 80

By: Swaab

Hardcover Published: 30th December 2003
ISBN: 9780444514905
Number Of Pages: 616

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This volume in the Handbook of Clinical Neurology (Series Editors: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; Fran‡ois Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands)is the first major account of the human hypothalamus. Part II is system and disease oriented and deals with the clinic, and with the neuropathology, neurobiology and genetics of vascular disorders, disorders of development and growth (including e.g. anencephaly, septo-optic dysplasia and other midline defects), hypothalamic and pineal tumors, infections, neuroimmunological disorders such as neurosarcoidosis, multiple sclerosis, and Langerhans-cell histiocytosis. After the neuropathology of the neurohypophysis has been dealt with, the background of the different forms of diabetes insipidus and other drinking disorders, such as polydipsia and adipsia, inappropriate secretion of vasopressin, and Wolfram syndrome are presented. Eating disorders such as, e.g. Prader-Willi syndrome, anorexia and bulimia nervosa, are presented as typical hypothalamic diseases. Genetic disorders causing a defect in the migration of hypothalamic neurons are the basis of Kallmann syndrome. Sexual differentiation of the brain is related to transsexuality and homo/heterosexuality.

In these "collected works" hypothalamic involvement is demonstrated in lower, as well as many higher functions, and even in neurologic and psychiatric disorders, such as memory and attention deficits, mood and depression, narcolepsy, cluster headache, and aggression-all conditions one would, intuitively, not associate with the hypothalamus. If one book can change the traditional clinical perception of the hypothalamus as an evoluntionary ancient, endocrine structure of little importance, this monograph will.
"Journal of Neuropathology and Experimental Neurology, March 2005"

Neuropathology of the Human Hypothalamus and Adjacent Brain Structures
Vascular supply and vascular disorders
Blood supply to the hypothalamus and pituitary
Vascular lesions of the hypothalamus. 17
Choroid plexus of the third ventricle
Disorders of development and growth
Transsphenoidal encephalocele and empty sella syndrome
Congenital midline defects: optic nerve hypoplasia and septo-optic dysplasia (De Morsier's syndrome)
Dystopia of the neurohypophysis
The optic chiasm
The growth hormone axis in development and aging
Septum pellucidum abnormalities
Symptoms due to hypothalamic tumors
Germinoma and teratoma
Craniopharyngioma, Rathke's cleft cysts and xanthogranuloma
Dermoid and epidermoid tumors
Pineal region tumors
Tuberous sclerosis (Bourneville-Pringle syndrome) and tumors of the hypothalamus
Other tumors
Hypothalamic infections
Inflammatory conditions affecting the hypothalamus
Encephalitis lethargica (Von Economo's encephalitis)
Acquired immunodeficiency syndrome (AIDS)
Neuroimmunological disorders
Neurosarcoidosis of the hypothalamus
Multiple sclerosis (MS) and the hypothalamus
Langerhans' cell histiocytosis (Hand-Schnller-Christian disease; histiocytosis-X)
Other neuroimmunological hypothalamic disorders and lesions
Drinking disorders
Pathology of the neurohypophysis
Diabetes insipidus
Primary polydipsia and adipsia
Nocturnal diuresis
Vasopressin hypersecretion in diabetes mellitus
Inappropriate secretion of vasopressin
Wolfram's syndrome
Eating disorders
Prader-Willi syndrome
Anorexia nervosa and bulimia nervosa
Other eating disorders
Reproduction, olfaction and sexual behavior
Disorders of gonadotropic hormone regulation
Olfaction, anosmia, the vomeronasal organ (Jacobson's organ) and the embryology of LHRH neurons
Kallmann's syndrome
Klinefelter's syndrome or testicular dysgenesis
Sexual differentiation of the brain and sexual behavior
Hypothalamic lesions following trauma and iatrogenic disorders
Head/brain injury
Neuroleptic malignant syndrome
Hypothalamic injury by radiation
Lesion of the pituitary stalk
Hypothalamic involvement in psychiatric disorders
Psychiatric symptoms due to tumors of the third ventricle
Attacks of laughter (gelastic epilepsy)
Ventromedial hypothalamus syndrome and the effect of lesions on aggression
Depression and mania
The hypothalamus in mental deficiency
Obsessive-compulsive disorder
Anxiety disorders
Fatigue syndromes
Aggressive behavior
Schizophrenia and autism
Periodic disorders
Kleine-Levin syndrome (periodic somnolence and morbid hunger)
Spontaneous periodic fever, hypothermia, Shapiro syndrome and periodic Cushing's syndrome
Acute intermittent porphyria
Epileptic seizures
Neurodegenerative disorders
Alzheimer's disease and the hypothalamus
Dementia with argyrophilic grains
Parkinson's disease
Huntington's disease
Wernicke's encephalopathy, Korsakoff's psychosis and Marchiafava-Bignami disease
Adrenomyeloneuropathy, adrenoleukodystrophy and hypothalamic-pituitary dysfunction
Other neurodegenerative disorders
Autonomic disorders
Temperature regulation
Disturbed thermoregulation
Cardiovascular regulation
Cardiovascular disturbances
Circumventricular organs: lamina terminalis, subfornical organ and autonomic regulation
Pain and addiction
Opioid peptides and other addictive compounds
Pain and the hypothalamus. 31
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780444514905
ISBN-10: 0444514902
Series: Handbook of Clinical Neurology : Book 80
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 616
Published: 30th December 2003
Publisher: Elsevier Science & Technology
Country of Publication: GB
Dimensions (cm): 26.04 x 19.05  x 3.81
Weight (kg): 2.02

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