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This, the latest in the Sambrook and Tooze Guidebook Series enables non-specialists to rapidly gain access to unfamiliar work surrounding the secretory pathways. Detailing both the established and the experimental, this book outlines how recent work has established a role for the secretory pathway in the regulation of gene expression and cell-cycle control, clearly highlighting its importance. Addressing many aspects of the secretory pathway, the book contains almost two hundred entries, and falls in five sections: protein secretion in E.coli; translocation and maturation of newly synthesized polypeptides in the ER of eukaryotic cells; protein machines and catalyzing ER to golgi transport; membrane traffic in the golgi and to the cell surface, and membrane traffic to the lysosome/vacuole. Providing key references in a clear, informative layout, this book provides a valuable guide to the bewildering and complex array of genes and proteins involved in the cellular secretory pathway. The guidebook will maintain up to date entries - the almost two hundred contributors will update their entries continuously, and these updates will be available via the Internet.
'...a most convincing approach for rapid and thorough information...The different entries of the catalogues are written by leading specialists in the respective field and they are all impressive in their preciseness, clarity and information density. The volumes shold be present in every biochemical laboratory and other institutions in the field of molecular and cell biology.' * G.Aumuller. * The strength of the book is that it collects a vast amount of published data in a readily accessible form. If you keep getting lost among the thickets of membrane traffic, this guidebook will lead you to safety. * Regis B. Kelly, University of California, San Francisco, Trends in Cell Biology, Vol 5, June 1995 * this book will be welcomed in labs working on the secretory pathway, as it is the firt such components guide to become available and will help us keep track of all the SECs, VPSs, PEPs and COPs * Sean Munro, MRC Laboratory of Molecular Biology, TIBS, February 1995 *
Number Of Pages: 320
Published: 4th March 2002
Country of Publication: GB
Dimensions (cm): 24.33 x 18.8 x 1.75
Weight (kg): 0.57