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Growth Factors and the Cardiovascular System : DEVELOPMENTS IN CARDIOVASCULAR MEDICINE - P. Cummins

Growth Factors and the Cardiovascular System

DEVELOPMENTS IN CARDIOVASCULAR MEDICINE

By: P. Cummins (Editor)

Hardcover

Published: March 1999
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This book is the first to cover the growing area of research in growth factors and which devotes itself completely to the role of the growth factors in the cardiovascular system. It contains contributions by the leading experts in the field with an emphasis on the effects of growth factors on the cardiac myocyte, angiogenesis and atherosclerosis. Clinical and therapeutic implications of growth factors in cardiovascular disease are reviewed. Growth Factors and Cardiovascular System provides a comprehensive review together with new information that should be valuable to investigators and clinicians alike.

List of Contributors
Foreword
Preface
Introduction
Growth Factors: In vivo function and mechanism of actionp. 1
Growth factors in the heart
Fibroblast and transforming growth factors in the heart: A role in cardiac growth?p. 17
Growth factors and the cardiac extra-cellular matrixp. 31
Growth factors and the cardiac myocyte
Transforming growth factor-[beta]: Localization and possible functional roles in cardiac myocytesp. 45
Basic fibroblast growth factor in cardiac myocytes: expression and effectsp. 55
Growth factor signal transduction in the cardiac myocyte: Functions of the serum response elementp. 77
Effects of growth factors on human cardiac myocytesp. 105
Growth factors and angiogenesis
Growth factors and development of coronary collateralsp. 119
The role of growth factors in angiogenesisp. 149
Growth factors and atherosclerosis
Atherosclerosis and platelet derived growth factorsp. 169
Effects of TGF-[beta] on vascular smooth muscle cell growthp. 189
Some aspects of growth signal transduction in vascular smooth muscle cellsp. 207
Basic FGFs role in smooth muscle cell proliferation: A basis for molecular atherectomyp. 227
Growth factors and cardiovascular disease: Clinical and therapeutic implications
Role of transforming growth factor [beta] in cardioprotection of the ischemic-reperfused myocardiump. 249
Platelet-derived growth factor release after angioplastyp. 261
Platelet-derived growth factor (PDGF) receptor induced by vascular injuryp. 275
Growth factors and hypertension: Implications for a role in vascular remodellingp. 287
Transforming growth factor-[beta] induction in carcinoid heart diseasep. 311
Growth factor effects on the myocardium
Adrenergic stimulation and growth factor activityp. 321
Effects of transforming growth factor-beta on cardiac fibroblastsp. 337
Transforming growth factor [beta]s and cardiac developmentp. 347
Indexp. 367
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792324010
ISBN-10: 0792324013
Series: DEVELOPMENTS IN CARDIOVASCULAR MEDICINE
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 370
Published: March 1999
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 24.13 x 16.51  x 2.54
Weight (kg): 0.84