Growth Factors and the Cardiovascular System

By: P. Cummins (Editor)

Write A Review

Hardcover | 1 March 1999

At a Glance

Hardcover
392 Pages

Dimensions(cm)
24.13 x 16.51 x 2.54

Hardcover

$329.00

or 4 interest-free payments of $82.25 with

Ships in 5 to 7 business days

Nature is totally amoral! There are at least 3-4 million people in France alone who suffer from arterial hypertension, and whose cardiovascular system is submitted day and night to both a haemodynamic and hormonal stress. In all cases, the vasculature hypertrophies as does the myocardium. This growth process is obviously mainly detrimental at the outset since it lowers compliance of the arteries and makes them stiffer. In contrast, myocardial hypertrophy is initially beneficial since the growth process multiplies the number of contractile units and by so doing improves external work. In addition, according to Starling's law, wall stress is lowered. Growth factors playa major role in this amoral process as a trigger for hypertrophy at the vascular level, and very likely at the level of the myocardium. Another major point of interest is the role of growth factors as determinants of restenosis after angioplasty and also of atherogenesis. Several chapters in this book are directly or indirectly concerned with this problem which is far from being purely academic since several groups are currently trying to control these processes by gene transfer. Certainly, one of the major clinical questions arising from such studies is why restenosis is not more frequent in clinical practice. After de-endotheliazation, the biologist would predict on the basis of recent studies on growth factors, and in contrast with current clinical opinion, that hypertrophy would occur in all cases with more or less complete restenosis.

Shipping

	Standard Shipping	Express Shipping
Metro postcodes:	$9.99	$14.95
Regional postcodes:	$9.99	$14.95
Rural postcodes:	$9.99	$14.95

How to return your order

At Booktopia, we offer hassle-free returns in accordance with our returns policy. If you wish to return an item, please get in touch with Booktopia Customer Care.

Additional postage charges may be applicable.

Defective items

If there is a problem with any of the items received for your order then the Booktopia Customer Care team is ready to assist you.

For more info please visit our Help Centre.

You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Cardiovascular Medicine Science Biology, Life Sciences Biochemistry Pre-Clinical Medicine & Basic Sciences Physiology Gardening Medicine in General

List of Contributors
Foreword
Preface
Introduction
Growth Factors: In vivo function and mechanism of action	p. 1
Growth factors in the heart
Fibroblast and transforming growth factors in the heart: A role in cardiac growth?	p. 17
Growth factors and the cardiac extra-cellular matrix	p. 31
Growth factors and the cardiac myocyte
Transforming growth factor-[beta]: Localization and possible functional roles in cardiac myocytes	p. 45
Basic fibroblast growth factor in cardiac myocytes: expression and effects	p. 55
Growth factor signal transduction in the cardiac myocyte: Functions of the serum response element	p. 77
Effects of growth factors on human cardiac myocytes	p. 105
Growth factors and angiogenesis
Growth factors and development of coronary collaterals	p. 119
The role of growth factors in angiogenesis	p. 149
Growth factors and atherosclerosis
Atherosclerosis and platelet derived growth factors	p. 169
Effects of TGF-[beta] on vascular smooth muscle cell growth	p. 189
Some aspects of growth signal transduction in vascular smooth muscle cells	p. 207
Basic FGFs role in smooth muscle cell proliferation: A basis for molecular atherectomy	p. 227
Growth factors and cardiovascular disease: Clinical and therapeutic implications
Role of transforming growth factor [beta] in cardioprotection of the ischemic-reperfused myocardium	p. 249
Platelet-derived growth factor release after angioplasty	p. 261
Platelet-derived growth factor (PDGF) receptor induced by vascular injury	p. 275
Growth factors and hypertension: Implications for a role in vascular remodelling	p. 287
Transforming growth factor-[beta] induction in carcinoid heart disease	p. 311
Growth factor effects on the myocardium
Adrenergic stimulation and growth factor activity	p. 321
Effects of transforming growth factor-beta on cardiac fibroblasts	p. 337
Transforming growth factor [beta]s and cardiac development	p. 347
Index	p. 367
Table of Contents provided by Blackwell. All Rights Reserved.

Growth Factors and the Cardiovascular System

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

More in Medicine in General

The Brain Cliff

Brain Defenders

How to Protect Your Brain for Life

Make Me Well

A Quest to Understand the Confusing World of Wellness

The Fast 800 GLP-1 Recipe Book

Super Agers

An Evidence-Based Approach to Longevity

Sentinels

when diseases spread between animals and humans

Simple Kitchen Magic

Whole-Food Recipes and Remedies for a Holistic Life: A Cookbook

Hormone Health is Mental Health

How perimenopause hijacks your brain - and how to reclaim yourself

The Wanted and the Unwanted

Gray's Anatomy for Students

5th Edition

The Australian Policy Handbook

7th Edition - A Practical Guide to the Policymaking Process

Art Cure

Longlisted for the 2026 Womens Prize for Non-Fiction - The science of how the arts transform our health

Cure Your Fatigue, Second Edition

The Root Cause and How to Fix It On Your Own

The Food For Life Cookbook

100+ Recipes Created with ZOE

Havard's Nursing Guide to Drugs

12th Edition

Mediterranean Diet - The Australian Way

The new bestselling cookbook from Australia's favourite food site for fans of RecipeTin Eats, Jamie Oliver and Michael Mosley

The Doctor of Hiroshima

His heart-breaking and inspiring true life story

How to Starve Cancer

...and Then Kill It With Ferroptosis

Taking Charge of Adult ADHD: 2 Edition

Proven Strategies to Succeed at Work, at Home, and in Relationships

Dopamine Nation

Why our Addiction to Pleasure is Causing us Pain

The Fast 800 Keto (Australian & New Zealand Edition)

Eat well, burn fat, manage your weight long term

Post-Mortem

Tales of the macabre, hilarious and downright bizarre, from those who work with death

No-Nonsense Nutrition

Science-based Principles and Easy Recipes to Reset Appetite, Boost Energy, Feel Amazing and Transform Your Health

The Energy Game

A Science-backed System to Recharge Without Pressing Pause on Life

This product is categorised by

Longlisted for the 2026 Womens Prize for Non-Fiction - The science of how the arts transform our health