Goat Man Murder is based on the unsolved murder of Miss Josephine Meredith committed in the 1930's in Natchez, Mississippi. Prior to being murdered she shoots a goats whose owners live in a decaying antebellum mansion, Glendarrow, next to her perfectly groomed Meredith Manor. The eccentric "goat couple," Jonathan Darrow and Miss Livy, love their goats and become prime suspects in her murder. But so is another eccentric, Penelope, whose jealousy over her brother Donald Major's twenty-year affair with Miss Meredith leads her to contemplate suicide. Slowly going mad, she spends her days dressed in a white peignoir in the cupola of their home. However, the physical evidence for the murder points to an employee of Miss Meredith, "Old Tin," a black man.