Glycopeptide Antibiotics

By: Ramakris Nagarajan (Editor)

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Hardcover | 2 May 1994 | Edition Number 1

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Describing all known assays used to discover new glycopeptide antibiotics, this outstanding reference discusses practical techniques for screening, isolating, and analyzing glycopeptide antibiotics - correlating structure-activity relationships with the mode of action.
Classifying glycopeptide antibiotics according to differences in the chemical structure of the core heptapeptide aglycone, Glycopeptide Antibiotics examines every relevant chemical aspect of the carbohydrate components of glycopeptide antibodies ... details the purification of glycopeptide antibodies from fermentation broths ... contains an exhaustive survey of synthetic routes to the 3-amino-2,3,6-trideoxyhexoses ... reviews advances made towards the total synthesis of vancomycin and other similar chemical structures ... investigates the analytical quantitation, characterization, pharmacokinetics, clinical uses, and safety profile of vancomycin and related glycopeptides ... delineates the discovery, chemistry, antimicrobial activity, pharmacokinetics, and toxicology of teicoplanin ... explores the problem of resistance with glycopeptide antibodies ... and much more.
Exhaustively referenced furnishing over 1650 literature citations, Glycopeptide Antibiotics is an invaluable resource for industrial, clinical, and research pharmacists; pharmacologists; organic and medicinal chemists; pharmaceutical research and development managers; microbiologists; and graduate students in these disciplines.

Industry Reviews

." . .a comprehensive treatment of all aspects of vancomycin and related glycopeptide antibiotics, including their discovery, isolation, purification, analysis, synthesis, mode of action, SAR, and microbial resistance, as well as the clinical application of these important compounds. . . . . .a valuable text. . .a useful library addition." ---Journal of the American Chemical Society ." . .a well written and produced book which succeeds in its aim of producing an authoritative one volume coverage of the current knowledge on the glycopeptide antibiotics. . . . . .of great interest to researchers. . .an important reference source for all involved with. . .glycopeptides." ---Journal of Pharmacy and Pharmacology

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