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Glaucoma : Essentials in Ophthalmology - Franz Grehn


Essentials in Ophthalmology

By: Franz Grehn (Editor), Robert Stamper (Editor)

Hardcover Published: 25th May 2004
ISBN: 9783540406082
Number Of Pages: 232

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"Essentials in Ophthalmology" is a new review series covering all of ophthalmology categorized in eight subspecialties. It will be published quarterly, thus each subspecialty will be reviewed biannually.
Given the multiplicity of medical publications already available, why is a new series needed? Consider that the half-life of medical knowledge is estimated to be around 5 years. Moreover, it can be as long as 8 years between the first description of a medical innovation in a peer-reviewed scientific journal and publication in a medical textbook. A series that narrows this time span between journal and textbook would provide a more rapid and efficient transfer of medical knowledge into clinical practice, and enhance care of our patients.

Industry Reviews

From the reviews: "The Essentials in Ophthalmology series attempts to bridge the time gap between journal publications and up-to-date textbook distillation of medical knowledge. ! The editors of this series have cleverly packaged information in a format that will keep clinicians on the forefront of thoughts in the different disciplines of ophthalmology. ! Readers will be relieved and undoubtedly satisfied with this concise text that provides clinically useful updates in important areas of glaucoma diagnosis and management." (L. J. Katz, Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 244, 2006)

Genetic Changes and Their Influence on Structure and Function of the Eye in Glaucoma
Introductionp. 1
Glaucoma in Developmental Disordersp. 2
Development of the Ocular Mesenchyme in the Anterior Eyep. 2
Axenfeld-Rieger's Syndrome, Peters' Anomaly and Anterior Segment Dysgenesisp. 4
Aniridiap. 9
Primary Congenital Glaucomap. 11
Nail-Patella Syndromep. 13
Genes and Primary Open-Angle Glaucoma (POAG)p. 13
Loci for POAGp. 14
Myocilinp. 15
Optineurinp. 19
Genes and Pigmentary Glaucomap. 21
Referencesp. 21
Neuroprotection in Glaucoma
Introductionp. 29
Basicsp. 29
Rationale for Neuroprotection in Glaucomap. 30
Necessary Steps for Neuroprotectionp. 31
Preclinical Evidence for Neuroprotection in Glaucomap. 31
NMDA Receptor Antagonistsp. 31
2-Adrenergic Receptor Agonistsp. 32
ß1-Adrenergic Receptor Antagonistsp. 32
Nitric Oxide Synthase Antagonistsp. 33
Reactive Oxygen Species Scavengers and Lipid Peroxidation Inhibitorsp. 33
Neurotrophic Factorsp. 33
Vaccinationp. 34
Clinical Experience with the Described Substancesp. 34
Current Clinical Practice/Recommendationsp. 36
Referencesp. 36
Screening for Glaucoma
Introductionp. 39
Why Screen for Glaucoma?p. 40
The Burden of Untreated Diseasep. 40
The Importance of Early Detectionp. 41
The Lack of Knowledge Regarding Glaucoma in the Lay Communityp. 41
Current Screening Practices and Experiencep. 42
Specific Screening Testsp. 43
Rationale for a Risk Factor Questionnairep. 43
Frequency-Doubling Technologyp. 43
Scanning Laser Polarimetryp. 44
The Promise of Teleophthalmologyp. 46
The Cost-Effectiveness of Screening for Glaucomap. 46
Referencesp. 49
Semi-automated Kinetic Perimetry for Assessment of Advanced Glaucomatous Visual Field Loss
Introductionp. 51
Methods/Methodological Aspectsp. 52
Assessment and Definition of "Local Kinetic Threshold" and Local Scatterp. 57
Assessment and Importance of Individual Reaction Timep. 57
Selection of Optimum Target Angular Velocityp. 58
Age-Related Normative Valuesp. 58
Comparability of SKP Results with Those of Conventional Manual Kinetic Perimetry Using the GOLDMANN Instrumentp. 58
Evaluation of Individual Functional Impairment/Expert Opinionp. 59
Training, Education and Learningp. 59
Outlookp. 59
Referencesp. 60
Optic Nerve Imaging: Recent Advances
Introductionp. 63
Backgroundp. 63
Image Qualityp. 65
Reproducibilityp. 66
Detecting Glaucomap. 66
Association Between Structure and Functionp. 66
Detecting Change Over Timep. 66
Confocal Scanning Laser Ophthalmoscopyp. 67
Backgroundp. 67
Image Qualityp. 71
Reproducibilityp. 71
Detecting Early to Moderate Glaucomap. 72
Relationship Between Structure and Functionp. 72
Detecting Change Over Timep. 72
Strengths and Limitationsp. 74
Scanning Laser Polarimetryp. 74
Backgroundp. 74
Image Qualityp. 76
Reproducibilityp. 76
Detecting Early to Moderate Glaucomap. 76
Relationship Between Structure and Functionp. 78
Detecting Change Over Timep. 78
Strngths and Limitationsp. 78
Optical Coherence Tomographyp. 79
Backgroundp. 79
Image Qualityp. 81
Reproducibilityp. 82
Detecting Early to Moderate Glaucomap. 82
Relationship Between Structure and Functionp. 83
Detection of Longitudinal Change over Timep. 84
Strengths and Limitationsp. 85
Scanning Retinal Thickness Analyzerp. 85
Backgroundp. 85
Image Qualityp. 86
Reproducibilityp. 86
Discriminating Between Healthy Eyes and Eyes with Early to Moderate Glaucomap. 86
Relationship Between Structure and Functionp. 86
Detecting Change Over Timep. 87
Strengths and Limitationsp. 87
Conclusionsp. 87
Referencesp. 88
New Concepts in the Diagnosis of Angle-Closure Glaucoma: The Role of Ultrasound Biomicroscopy
Introductionp. 93
Ultrasound Biomicroscopyp. 94
The Normal Eyep. 96
Anatomical Classification of the Angle-Closure Glaucomasp. 96
Pupillary Blockp. 96
Plateau Irisp. 99
Pseudoplateau Irisp. 100
Lens-Related Angle-Closurep. 100
Malignant Glaucomap. 102
Conclusionp. 103
Referencesp. 103
Childhood Glaucoma and Amblyopia
Introductionp. 105
Patient Evaluationp. 106
Clinical Featuresp. 106
Examination Under Sedationp. 106
Examination Under Anesthesia (EUA)p. 107
Special Diagnostic Testsp. 109
Medical Managementp. 109
Indicationsp. 109
Efficacy and Safetyp. 109
Surgical Managementp. 110
Goniotomyp. 110
Trabeculotomyp. 111
Trabeculectomyp. 113
Goniotomy versus Trabeculotomy versus Trabeculectomy versus Other Proceduresp. 115
Glaucoma Drainage Implantsp. 117
Cyclodestructive Proceduresp. 118
Postoperative Managementp. 119
Periodic Clinical Examinationp. 119
Management of Amblyopiap. 119
Genetic Counselingp. 121
Conclusionsp. 121
Referencesp. 122
What Have We Learned from the Major Glaucoma Clinical Trials?
Introductionp. 125
Advanced Glaucoma Intervention Study (AGIS)p. 127
Collaborative Normal Tension Glaucoma Study (CNTGS)p. 129
Collaborative Initial Glaucoma Treatment Study (CIGTS)p. 130
Ocular Hypertension Treatment Study (OHTS)p. 131
Early Manifest Glaucoma Trial (EMGT)p. 135
Conclusionsp. 136
Referencesp. 136
The Concept of Target IOP at Various Stages of Glaucoma
Introductionp. 139
The Relationship Between IOP and the Risk of Visual Field Progressionp. 140
Target Pressures in Glaucoma Managementp. 140
Target Pressurep. 140
Randomized Controlled Trials and Target IOPsp. 143
Referencesp. 145
A Practical Approach to the Management of Normal Tension Glaucoma
Introductionp. 147
Backgroundp. 147
Differential Diagnosisp. 148
Investigationp. 151
Investigation for the Purpose of Managementp. 152
Managementp. 153
Referencesp. 155
Pseudoexfoliation Glaucoma
Backgroundp. 157
Pathobiology of PEX Syndromep. 158
Pathogenesisp. 158
Pathogenetic Factorsp. 160
Pathogenetic Conceptp. 160
Etiologyp. 160
Clinical Diagnosisp. 161
Manifest PEX Syndromep. 161
Masked PEX Syndromep. 163
Early Stages of PEX Syndromep. 164
Asymmetry of Involvementp. 164
Differential Diagnosisp. 164
Open-Angle Glaucoma in PEX Syndromep. 165
Epidemiologyp. 165
Clinical Featuresp. 165
Pathomechanisms of Glaucoma Developmentp. 166
Acute Open-Angle Glaucomap. 170
Angle-Closure Glaucoma in PEX Syndromep. 170
Managementp. 171
Medical Therapyp. 172
Laser Trabeculoplastyp. 172
Filtration Surgeryp. 172
Summary and Perspectivesp. 173
Referencesp. 174
Pigment Dispersion Syndrome-Update 2003
Introductionp. 177
Clinical Findingsp. 177
Anterior Segmentp. 177
Posterior Segmentp. 179
Pathophysiologyp. 179
Developmental Abnormalities Underlying PDSp. 181
Blinkingp. 182
Accommodationp. 183
Exercisep. 183
Clinical Correlationsp. 183
Heredityp. 183
Genderp. 183
Racep. 184
Refractive Errorp. 184
Asymmetric Involvementp. 184
Natural Historyp. 184
Active Phasep. 184
Regression Phasep. 185
Conversion to Glaucomap. 185
Differential Diagnosisp. 185
Treatmentp. 186
Referencesp. 188
Wound Modulation in Glaucoma Surgery
Introductionp. 193
Basicsp. 193
Wound Healing Following Trabeculectomyp. 193
Therapeutic Optionsp. 194
Clinical Experience with the Described Substancesp. 196
Corticosteroidsp. 196
5-Fluorouracilp. 197
Mitomycinp. 199
Transforming Growth Factor-ßp. 205
Suraminp. 206
Additional Substancesp. 206
Current Clinical Practice/Recommendationsp. 206
Post-operative Intensified Carep. 207
Referencesp. 207
Non-penetrating vs Penetrating Surgery of Primary Open-Angle Glaucoma
Introductionp. 209
Basicsp. 209
Non-penetrating vs Penetrating Procedures: Clinical Evaluationp. 211
Efficacyp. 211
Safetyp. 212
Affordabilityp. 213
Conclusionsp. 214
Referencesp. 214
Subject Indexp. 217
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9783540406082
ISBN-10: 3540406085
Series: Essentials in Ophthalmology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 232
Published: 25th May 2004
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 24.4 x 17.0  x 1.91
Weight (kg): 0.72

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