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Genome Transcriptome and Proteome Analysis - Alain Bernot

Genome Transcriptome and Proteome Analysis

Hardcover Published: 1st October 2004
ISBN: 9780470849545
Number Of Pages: 248

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<i><b>Genome Transcriptome and Proteome Analysis</b></i> is a concise introduction to the subject, successfully bringing together these three key areas of research. Starting with a revision of molecular genetics the book offers clear explanations of the tools and techniques widely used in genome, transcriptome and proteome analysis. Subsequent chapters offer a broad overview of linkage maps, physical maps and genome sequencing, with a final discussion on the identification of genes responsible for disease. <p> An invaluable introduction to the basic concepts of the subject, this text offers the student an excellent overview of current research methods and applications and is a good starting point for those new to the area. <ul> <li>A clear, concise introduction to the subject of modern genomic analysis <li>A technology-oriented approach including the latest developments in the field <li>Invaluable to those students taking courses in Bioinformatics, Human Genetics, Biochemistry and Molecular Biology&#160; </ul>


1 General introduction.

1.1 Revision of molecular genetics.

1.2 The tools of molecular biology.

1.3 Specifics of the genome programmes.

1.4 The species analysed.

2 Linkage maps.

2.1. Tools and methods in genetic mapping.

2.2 The development of genetic maps.

2.3 Radiation hybrid maps.

2.4 Conclusion.

3 Physical maps.

3.1 Local maps or small genomes.

3.2 Strategies for physical mapping of the human genome.

3.3 Maps of the human genome.

3.4 Conclusion.

4 Genome sequencing .

4.1 Strategic choices.

4.2 Prokaryotic genomes.

4.3 Genomes of model eukaryotes.

4.4 The human genome. & lt;div>

4.5 Conclusion.

5 Sequencing cDNA and the transcriptome.

5.1 Strategies of cDNA sequencing.

5.2 The economic stakes.

5.3 The analysis of cDNA sequences.

5.4 The transcriptome.

5.5 Conclusion.

6 The proteome.

6.1 Basic techniques.

6.2 Transgenesis .

6.3 Mutagenesis.

6.4 Two-dimensional electrophoresis and identification of proteins.

6.5 Identification of protein interactions by twin hybrids.

6.6 Chip technology.

6.7 Analysis of three-dimensional structure.

6.8 Conclusions.

7 Identification of genes responsible for disease.

7.1 Genetic diseases.

7.2 Functional cloning and chromosomal anomalies.

7.3 Strategy for positional cloning.

7.4 What is the future for the cloning of disease-causing genes?

7.5 Conclusion.

General conclusion.


ISBN: 9780470849545
ISBN-10: 0470849541
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 248
Published: 1st October 2004
Publisher: John Wiley and Sons Ltd
Country of Publication: GB
Dimensions (cm): 23.4 x 15.45  x 1.84
Weight (kg): 0.47
Edition Number: 1