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Hardcover
Published: 1st October 2004
ISBN: 9780470849545
Number Of Pages: 248
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Published: 1st October 2004<i><b>Genome Transcriptome and Proteome Analysis</b></i> is a concise introduction to the subject, successfully bringing together these three key areas of research. Starting with a revision of molecular genetics the book offers clear explanations of the tools and techniques widely used in genome, transcriptome and proteome analysis. Subsequent chapters offer a broad overview of linkage maps, physical maps and genome sequencing, with a final discussion on the identification of genes responsible for disease. <p> An invaluable introduction to the basic concepts of the subject, this text offers the student an excellent overview of current research methods and applications and is a good starting point for those new to the area. <ul> <li>A clear, concise introduction to the subject of modern genomic analysis <li>A technology-oriented approach including the latest developments in the field <li>Invaluable to those students taking courses in Bioinformatics, Human Genetics, Biochemistry and Molecular Biology  </ul>
1 General introduction.
1.1 Revision of molecular genetics.
1.2 The tools of molecular biology.
1.3 Specifics of the genome programmes.
1.4 The species analysed.
2 Linkage maps.
2.1. Tools and methods in genetic mapping.
2.2 The development of genetic maps.
2.3 Radiation hybrid maps.
2.4 Conclusion.
3 Physical maps.
3.1 Local maps or small genomes.
3.2 Strategies for physical mapping of the human genome.
3.3 Maps of the human genome.
3.4 Conclusion.
4 Genome sequencing .
4.1 Strategic choices.
4.2 Prokaryotic genomes.
4.3 Genomes of model eukaryotes.
4.4 The human genome. & lt;div>
4.5 Conclusion.
5 Sequencing cDNA and the transcriptome.
5.1 Strategies of cDNA sequencing.
5.2 The economic stakes.
5.3 The analysis of cDNA sequences.
5.4 The transcriptome.
5.5 Conclusion.
6 The proteome.
6.1 Basic techniques.
6.2 Transgenesis .
6.3 Mutagenesis.
6.4 Two-dimensional electrophoresis and identification of proteins.
6.5 Identification of protein interactions by twin hybrids.
6.6 Chip technology.
6.7 Analysis of three-dimensional structure.
6.8 Conclusions.
7 Identification of genes responsible for disease.
7.1 Genetic diseases.
7.2 Functional cloning and chromosomal anomalies.
7.3 Strategy for positional cloning.
7.4 What is the future for the cloning of disease-causing genes?
7.5 Conclusion.
General conclusion.
Bibliography.
ISBN: 9780470849545
ISBN-10: 0470849541
Audience:
Professional
Format:
Hardcover
Language:
English
Number Of Pages: 248
Published: 1st October 2004
Publisher: John Wiley and Sons Ltd
Country of Publication: GB
Dimensions (cm): 23.4 x 15.45
x 1.84
Weight (kg): 0.47
Edition Number: 1
