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Genetics of Colorectal Cancer for Clinical Practice : Developments in Oncology - Fred H. Menko

Genetics of Colorectal Cancer for Clinical Practice

Developments in Oncology

Hardcover Published: 31st July 1993
ISBN: 9780792321002
Number Of Pages: 187

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Colorectal cancer is a collective term for a heterogeneous group of diseases. In a large proportion of cases, the condition is attributable to genetic predisposition. Those directly involved in the treatment of patients with cancer of the large bowel are confronted to an increasing degree with the genetic aspects of the disease. In familial and hereditary forms of the disorder periodic screening of the close relatives of the patients can in principle prevent disease and death from colorectal cancer. Presymptomatic diagnosis by means of DNA technology is now possible in many cases of familial adenomatous polyposis. Genetic diagnosis will be increasingly important for the identification of high-risk groups.
This book summarizes those aspects of the genetics of colorectal cancer that are important for clinical pracice. It has been stated that clinicians can contribute to the goal of reducing mortality from cancer by asking each patient about his or her family history of cancer. The aim of this book is to provide a guideline for the management of those situations in which the family history of colorectal cancer is found to be positive.

`This book is well written and provides an excellent overview of hereditary colorectal cancer for all clinicians confronted with patients with colorectal cancer. It is hoped that this book will find broad clinical acceptance.' ECC Newsletter, 3:2 `It is presented in an attractive format and is highly recommended.' Cancer Forum, 18:3

Preface
Introductionp. 1
Genetic Predisposition and Illnessp. 6
Genes and Environmentp. 6
Modes of Inheritancep. 9
Autosomal Dominant Inheritancep. 15
Studies at the DNA Levelp. 17
Rare Genetic Mechanismsp. 28
General Aspects of Colorectal Cancerp. 31
Incidence and Mortalityp. 32
The Role of Dietp. 35
Tumour Localisation and Histological Typesp. 37
The Adenoma-Carcinoma Sequencep. 40
Estimation of Risk for Colorectal Cancerp. 46
Population Screeningp. 47
Groups at Increased Risk for Colorectal Cancerp. 50
Intervention Studiesp. 55
Familial and Hereditary Colorectal Cancerp. 58
Family Studies of Patients with Colorectal Cancerp. 58
Classification: Polyposis and Nonpolyposis Formsp. 61
Hereditary Colorectal Cancer without Polyposisp. 62
Hereditary Colorectal Cancer with Polyposisp. 83
Intermediate and Miscellaneous Formsp. 105
Risk Estimation for Family Membersp. 107
Screening of High-Risk Family Membersp. 108
Psychosocial Aspects of Familial Cancerp. 111
Mechanisms of Colorectal Carcinogenesisp. 113
Chromosomal Abnormalitiesp. 114
Oncogenes and Tumour Suppressor Genesp. 116
DNA Repair and Immunological Mechanismsp. 129
Proliferation Biomarkersp. 130
Tumour Biomarkersp. 133
Clinical Examplesp. 137
Guidelines for Clinical Practicep. 149
Bibliographyp. 157
Indexp. 178
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792321002
ISBN-10: 0792321006
Series: Developments in Oncology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 187
Published: 31st July 1993
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.4 x 15.6  x 1.2
Weight (kg): 1.03